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    Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68616, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gdpd3provided by MGI
    Official Full Name
    glycerophosphodiester phosphodiesterase domain containing 3provided by MGI
    Primary source
    MGI:MGI:1915866
    See related
    Ensembl:ENSMUSG00000030703 AllianceGenome:MGI:1915866
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110015E22Rik
    Summary
    Enables lysophospholipase activity and phosphoric diester hydrolase activity. Involved in N-acylethanolamine metabolic process and phosphatidylcholine catabolic process. Located in endoplasmic reticulum membrane and perinuclear region of cytoplasm. Orthologous to human GDPD3 (glycerophosphodiester phosphodiesterase domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 24.7), kidney adult (RPKM 15.0) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gdpd3 in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126365586..126374817)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126766414..126775645)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene U1 small nuclear ribonucleoprotein 1C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_20155 Neighboring gene mitogen-activated protein kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E6602 Neighboring gene yippee like 3 Neighboring gene T-box 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lysophospholipase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables lysophospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoric diester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoric diester hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lysophospholipase D GDPD3
    Names
    glycerophosphodiester phosphodiesterase 7
    glycerophosphodiester phosphodiesterase domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024228.2NP_077190.2  lysophospholipase D GDPD3

      See identical proteins and their annotated locations for NP_077190.2

      Status: VALIDATED

      Source sequence(s)
      AK003726, AW045753, BY101331
      Consensus CDS
      CCDS40130.1
      UniProtKB/Swiss-Prot
      Q99LY2, Q9D1C0
      Related
      ENSMUSP00000032944.8, ENSMUST00000032944.9
      Conserved Domains (2) summary
      cd08612
      Location:13310
      GDPD_GDE4; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE4 and similar proteins
      COG0584
      Location:34311
      UgpQ; Glycerophosphoryl diester phosphodiesterase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126365586..126374817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)