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    Tbc1d9 TBC1 domain family, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 71310, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbc1d9provided by MGI
    Official Full Name
    TBC1 domain family, member 9provided by MGI
    Primary source
    MGI:MGI:1918560
    See related
    Ensembl:ENSMUSG00000031709 AllianceGenome:MGI:1918560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933431N12Rik
    Summary
    Predicted to enable GTPase activator activity. Is expressed in dentate gyrus subgranular zone. Orthologous to human TBC1D9 (TBC1 domain family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 17.2), cerebellum adult (RPKM 17.2) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tbc1d9 in Genome Data Viewer
    Location:
    8 C2; 8 39.59 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (83891981..83999569)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83165352..83272940)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 150 Neighboring gene STARR-seq mESC enhancer starr_22071 Neighboring gene zinc finger protein 235 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22072 Neighboring gene STARR-positive B cell enhancer mm9_chr8:85599639-85599939 Neighboring gene predicted gene, 53443 Neighboring gene STARR-positive B cell enhancer ABC_E6665 Neighboring gene STARR-seq mESC enhancer starr_22076 Neighboring gene predicted gene, 53444 Neighboring gene predicted gene, 42027 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22078 Neighboring gene STARR-seq mESC enhancer starr_22080 Neighboring gene STARR-positive B cell enhancer ABC_E1762 Neighboring gene uncoupling protein 1 (mitochondrial, proton carrier) Neighboring gene ELMO/CED-12 domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111304.1NP_001104774.1  TBC1 domain family member 9 isoform 1

      See identical proteins and their annotated locations for NP_001104774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC166939, AI847101, AK134614, AK173050, BB396007, BE853276
      Consensus CDS
      CCDS52607.1
      UniProtKB/Swiss-Prot
      Q3UYK3, Q69ZW8, Q8BIJ5, Q8BVP3, Q9CUB3
      Related
      ENSMUSP00000091093.5, ENSMUST00000093393.5
      Conserved Domains (4) summary
      smart00164
      Location:512722
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:304399
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:157255
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
      cl08302
      Location:893923
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. NM_027758.4NP_082034.1  TBC1 domain family member 9 isoform 2

      See identical proteins and their annotated locations for NP_082034.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several alternate in-frame exons compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC122890, AC166939, AK049049
      Consensus CDS
      CCDS22448.1
      UniProtKB/TrEMBL
      Q6PGG9
      Related
      ENSMUSP00000034145.5, ENSMUST00000034145.11
      Conserved Domains (3) summary
      smart00164
      Location:279489
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cl08302
      Location:660690
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl17171
      Location:120166
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      83891981..83999569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243771.2XP_030099631.1  TBC1 domain family member 9 isoform X1

      UniProtKB/TrEMBL
      Q6PGG9
      Conserved Domains (4) summary
      smart00164
      Location:359569
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd13354
      Location:151246
      PH-GRAM2_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2
      cd13351
      Location:4102
      PH-GRAM1_TCB1D9_TCB1D9B; TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1
      cl08302
      Location:740770
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...