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    Usp19 ubiquitin specific peptidase 19 [ Mus musculus (house mouse) ]

    Gene ID: 71472, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp19provided by MGI
    Official Full Name
    ubiquitin specific peptidase 19provided by MGI
    Primary source
    MGI:MGI:1918722
    See related
    Ensembl:ENSMUSG00000006676 AllianceGenome:MGI:1918722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zmynd9; 8430421I07Rik
    Summary
    Enables K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of skeletal muscle tissue development; protein K48-linked deubiquitination; and protein stabilization. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 57.6), ovary adult (RPKM 50.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Usp19 in Genome Data Viewer
    Location:
    9 F2; 9 59.42 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108367806..108379536)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108490607..108502337)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch domain containing 8B Neighboring gene coiled-coil domain containing 71 Neighboring gene microRNA 12206 Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene laminin, beta 2 Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene glutamine-rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of proteasomal protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 19
    Names
    deubiquitinating enzyme 19
    ubiquitin specific protease 19
    ubiquitin thioesterase 19
    ubiquitin thiolesterase 19
    ubiquitin-specific processing protease 19
    NP_001161843.1
    NP_001161844.1
    NP_001161845.1
    NP_082080.3
    NP_663382.2
    XP_006511895.1
    XP_006511896.1
    XP_006511897.1
    XP_017169082.1
    XP_017169083.1
    XP_030100460.1
    XP_030100462.1
    XP_030100463.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168371.2NP_001161843.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 2

      See identical proteins and their annotated locations for NP_001161843.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region and has an alternate 3' exon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK159473, BC046824, BP762964, CJ075820
      Consensus CDS
      CCDS57702.1
      UniProtKB/TrEMBL
      A0A991ELD7, J3KMM1
      Related
      ENSMUSP00000135930.2, ENSMUST00000178075.8
      Conserved Domains (7) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10981255
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:541727
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:834876
      zf-MYND; MYND finger
      pfam14533
      Location:741797
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:416538
      USP19_linker; Linker region of USP19 deubiquitinase
    2. NM_001168372.2NP_001161844.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 3

      See identical proteins and their annotated locations for NP_001161844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 3' exon compared to variant 1. The resulting protein (isoform 3) has a distinct, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK160807, BP762964, CJ075820
      Consensus CDS
      CCDS52924.1
      UniProtKB/TrEMBL
      A0A991ELD7
      Related
      ENSMUSP00000082119.8, ENSMUST00000085044.14
      Conserved Domains (7) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:328424
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10971254
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:540726
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:833875
      zf-MYND; MYND finger
      pfam14533
      Location:740796
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:415537
      USP19_linker; Linker region of USP19 deubiquitinase
    3. NM_001168373.2NP_001161845.1  ubiquitin carboxyl-terminal hydrolase 19 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses alternate splice sites in the coding region and has an alternate 3' exon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK148412, BC046824, BP762964, BQ442290, BQ770257, CJ075820
      Consensus CDS
      CCDS81075.1
      UniProtKB/TrEMBL
      A0A0A6YWX1, A0A991ELD7
      Related
      ENSMUSP00000141738.2, ENSMUST00000193678.6
      Conserved Domains (7) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10961253
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:539725
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:832874
      zf-MYND; MYND finger
      pfam14533
      Location:739795
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:416536
      USP19_linker; Linker region of USP19 deubiquitinase
    4. NM_027804.4NP_082080.3  ubiquitin carboxyl-terminal hydrolase 19 isoform 1

      See identical proteins and their annotated locations for NP_082080.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI644135, AK146504, CJ075820
      Consensus CDS
      CCDS23529.1
      UniProtKB/Swiss-Prot
      Q3TAC9, Q3TUE6, Q3UJD6, Q6P9T0, Q80TP5, Q80ZW5
      UniProtKB/TrEMBL
      A0A991ELD7
      Related
      ENSMUSP00000006854.8, ENSMUST00000006854.13
      Conserved Domains (7) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:328424
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10971254
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:540726
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:833875
      zf-MYND; MYND finger
      pfam14533
      Location:740796
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:415537
      USP19_linker; Linker region of USP19 deubiquitinase
    5. NM_145407.3NP_663382.2  ubiquitin carboxyl-terminal hydrolase 19 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the middle coding region and has an alternate 3' exon compared to variant 1. The resulting isoform (5) lacks an internal segment and has a different and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK043088, BC046824, BP762964, CJ075820, CT010508
      Consensus CDS
      CCDS52925.1
      UniProtKB/TrEMBL
      A0A991ELD7, E9Q9M5
      Related
      ENSMUSP00000128573.3, ENSMUST00000166103.9
      Conserved Domains (7) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:328400
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      cd02674
      Location:10731230
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:516702
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam01753
      Location:809851
      zf-MYND; MYND finger
      pfam14533
      Location:716772
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam16602
      Location:391513
      USP19_linker; Linker region of USP19 deubiquitinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108367806..108379536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244603.1XP_030100463.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X7

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5361255
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:416538
      USP19_linker; Linker region of USP19 deubiquitinase
    2. XM_030244602.1XP_030100462.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X6

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:328424
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5331255
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:415535
      USP19_linker; Linker region of USP19 deubiquitinase
    3. XM_006511832.3XP_006511895.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

      See identical proteins and their annotated locations for XP_006511895.1

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5361258
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:416538
      USP19_linker; Linker region of USP19 deubiquitinase
    4. XM_006511834.2XP_006511897.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5361255
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:416538
      USP19_linker; Linker region of USP19 deubiquitinase
    5. XM_006511833.2XP_006511896.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5341256
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:416536
      USP19_linker; Linker region of USP19 deubiquitinase
    6. XM_017313593.2XP_017169082.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X5

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:329425
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5341253
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:416536
      USP19_linker; Linker region of USP19 deubiquitinase
    7. XM_030244600.2XP_030100460.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

      UniProtKB/TrEMBL
      A0A991ELD7
      Conserved Domains (4) summary
      cd06463
      Location:58140
      p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
      cd06466
      Location:328424
      p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
      COG5560
      Location:5331255
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:415535
      USP19_linker; Linker region of USP19 deubiquitinase
    8. XM_017313594.2XP_017169083.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X8

      UniProtKB/TrEMBL
      A0A0A6YWN9
      Related
      ENSMUSP00000141628.2, ENSMUST00000194171.6
      Conserved Domains (2) summary
      COG5560
      Location:27749
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam16602
      Location:129
      USP19_linker; Linker region of USP19 deubiquitinase