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    Ggnbp2 gametogenetin binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 217039, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ggnbp2provided by MGI
    Official Full Name
    gametogenetin binding protein 2provided by MGI
    Primary source
    MGI:MGI:2387356
    See related
    Ensembl:ENSMUSG00000020530 AllianceGenome:MGI:2387356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIF-3; Zfp403; D330017P12Rik
    Summary
    Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and spleen. Orthologous to human GGNBP2 (gametogenetin binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 45.3), liver E14 (RPKM 28.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ggnbp2 in Genome Data Viewer
    Location:
    11 C; 11 51.34 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84723187..84761668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84832361..84870837, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930502E09 gene Neighboring gene dehydrogenase/reductase 11 Neighboring gene STARR-positive B cell enhancer ABC_E3986 Neighboring gene STARR-seq mESC enhancer starr_30226 Neighboring gene STARR-seq mESC enhancer starr_30227 Neighboring gene STARR-positive B cell enhancer ABC_E7033 Neighboring gene gametogenetin binding protein 2, opposite strand Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX Neighboring gene zinc finger, HIT type 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage. Liu L, et al. Am J Pathol, 2017 Nov. PMID 28823874, Free PMC Article
    2. GGNBP2 is necessary for testis morphology and sperm development. Chen A, et al. Sci Rep, 2017 Jun 7. PMID 28592902, Free PMC Article
    3. GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis. Guo K, et al. Epigenetics, 2024 Dec. PMID 39109527
    4. Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice. Guo K, et al. J Cell Mol Med, 2018 Oct. PMID 30055035, Free PMC Article
    5. Dioxin induces a novel nuclear factor, DIF-3, that is implicated in spermatogenesis. Ohbayashi T, et al. FEBS Lett, 2001 Nov 23. PMID 11728448

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis.
      Title: GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis.
    2. Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation.
      Title: Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation.
    3. these data suggest that GGNBP2, likely mediated by its interaction with GGN1, plays a role in DNA double-strand break repair during meiotic progression of spermatocytes.
      Title: Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice.
    4. These results suggest that GGNBP2 plays a key role in spermatogenesis by affecting the morphology and function of SOX9-positive Sertoli cells.
      Title: GGNBP2 is necessary for testis morphology and sperm development.
    5. demonstrates that GGNBP2 is critically required for maintenance of the adhesion integrity of the adlumenal germ epithelium and is indispensable for normal spermatid transformation into mature spermatozoa in mice
      Title: Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage.
    6. GGNBP2 is an essential factor for pregnancy success acting through the maintenance of a balance of trophoblast stem cell proliferation and differentiation during placental development.
      Title: Ggnbp2 Is Essential for Pregnancy Success via Regulation of Mouse Trophoblast Stem Cell Proliferation and Differentiation.
    7. Ggnbp2 is mainly expressed in the testis. Its protein product interacted with GGN1 and could be involved in intracellular trafficking.
      Title: Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within labyrinthine layer development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of receptor signaling pathway via STAT IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gametogenetin-binding protein 2
    Names
    dioxin inducible factor 3
    gametogenin binding protein 2
    zinc finger protein 403

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364111.1 → NP_001351040.1  gametogenetin-binding protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL596083, AL645623
      UniProtKB/TrEMBL
      H7BX83

    2. NM_001364112.1 → NP_001351041.1  gametogenetin-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL596083, AL645623
      Consensus CDS
      CCDS88211.1
      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000018547.3, ENSMUST00000018547.9

    3. NM_001364114.1 → NP_001351043.1  gametogenetin-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596083, AL645623
      Consensus CDS
      CCDS88210.1
      UniProtKB/Swiss-Prot
      A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000130013.2, ENSMUST00000168434.8

    4. NM_001364115.1 → NP_001351044.1  gametogenetin-binding protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL596083, AL645623
      Consensus CDS
      CCDS88210.1
      UniProtKB/Swiss-Prot
      A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000098252.4, ENSMUST00000100686.10

    5. NM_153144.3 → NP_694784.2  gametogenetin-binding protein 2 isoform 3

      See identical proteins and their annotated locations for NP_694784.2

      Status: VALIDATED

      Source sequence(s)
      AB064543, AL645623, AY633741, BE982217
      Consensus CDS
      CCDS36262.1
      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000127584.2, ENSMUST00000172405.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      84723187..84761668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245848.2 → XP_030101708.1  gametogenetin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H7BX83

    2. XM_017314473.3 → XP_017169962.1  gametogenetin-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000103716.3, ENSMUST00000108081.9

    3. XM_030245849.1 → XP_030101709.1  gametogenetin-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      H7BX83

    4. XM_030245854.1 → XP_030101714.1  gametogenetin-binding protein 2 isoform X8

      UniProtKB/Swiss-Prot
      A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
      UniProtKB/TrEMBL
      H7BX83
      Related
      ENSMUSP00000117482.3, ENSMUST00000154915.9

    5. XM_030245853.1 → XP_030101713.1  gametogenetin-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      H7BX83

    6. XM_030245850.2 → XP_030101710.1  gametogenetin-binding protein 2 isoform X7

      UniProtKB/TrEMBL
      H7BX83

    7. XM_036156586.1 → XP_036012479.1  gametogenetin-binding protein 2 isoform X6

      UniProtKB/TrEMBL
      H7BX83

    8. XM_030245851.2 → XP_030101711.1  gametogenetin-binding protein 2 isoform X8

      UniProtKB/Swiss-Prot
      A4QPD5, B7ZP33, Q5SV75, Q5SV76, Q5SV77, Q5SV78, Q6GVH6, Q6P9J4, Q920N4
      UniProtKB/TrEMBL
      H7BX83

    9. XM_036156585.1 → XP_036012478.1  gametogenetin-binding protein 2 isoform X3

      UniProtKB/TrEMBL
      H7BX83

    10. XM_030245847.2 → XP_030101707.1  gametogenetin-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      H7BX83

    11. XM_030245846.2 → XP_030101706.1  gametogenetin-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      H7BX83

    12. XM_017314471.3 → XP_017169960.1  gametogenetin-binding protein 2 isoform X4

      UniProtKB/TrEMBL
      H7BX83

    13. XM_017314472.2 → XP_017169961.1  gametogenetin-binding protein 2 isoform X5

      UniProtKB/TrEMBL
      H7BX83
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SV77.1 GenPept UniProtKB/Swiss-Prot:Q5SV77

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