SMAD1 SMAD family member 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SMAD1provided by HGNC
Official Full Name: SMAD family member 1provided by HGNC
Primary source: HGNC:HGNC:6767
See related: Ensembl:ENSG00000170365 MIM:601595; AllianceGenome:HGNC:6767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in endometrium (RPKM 11.3), brain (RPKM 9.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q31.21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (145480770..145559176)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (148798276..148874991)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (146402458..146480328)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
Title: Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway.
Title: Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-betaR1/Smad axis.
Title: Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis.
The Interaction Between SMAD1 and YAP1 Is Correlated with Increased Resistance of Gastric Cancer Cells to Cisplatin.
Title: The Interaction Between SMAD1 and YAP1 Is Correlated with Increased Resistance of Gastric Cancer Cells to Cisplatin.
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions.
Title: BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions.
SMAD1 Loss-of-Function Variant Responsible for Congenital Heart Disease.
Title: SMAD1 Loss-of-Function Variant Responsible for Congenital Heart Disease.
Long noncoding RNA MALAT1 sponging miR-26a-5p to modulate Smad1 contributes to colorectal cancer progression by regulating autophagy.
Title: Long noncoding RNA MALAT1 sponging miR-26a-5p to modulate Smad1 contributes to colorectal cancer progression by regulating autophagy.
Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.
Title: Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.
HOXD13 suppresses prostate cancer metastasis and BMP4-induced epithelial-mesenchymal transition by inhibiting SMAD1.
Title: HOXD13 suppresses prostate cancer metastasis and BMP4-induced epithelial-mesenchymal transition by inhibiting SMAD1.
SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy.
Title: SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat-treated pulmonary arterial smooth muscle cells modulate levels of phosphorylated SMAD1/5/8 proteins and SMAD1/5/8-SMAD4 protein complex, which are repressed by cocaine exposure	PubMed
Vif	vif	HIV-1 Vif upregulates the expression of SMAD family member 1 (SMAD1) in Vif-expression T cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-143047 (e-PCR)
- UniSTS:171776

D4S2549E (e-PCR)
- UniSTS:64289

RH103506 (e-PCR)
- UniSTS:97831

SHGC-79334 (e-PCR)
- UniSTS:103240

B327ZG1 (e-PCR)
- UniSTS:82276

STS-Z39684 (e-PCR)
- UniSTS:49341

RH102368 (e-PCR)
- UniSTS:96702

ksks229 (e-PCR)
- UniSTS:514263

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables I-SMAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables I-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables co-SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables primary miRNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in BMP signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in SMAD protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in SMAD protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in SMAD protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in SMAD protein signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in cardiac conduction system development	NAS Non-traceable Author Statement more info	PubMed
involved_in cardiac muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in embryonic pattern specification	ISS Inferred from Sequence or Structural Similarity more info
involved_in gamete generation	IEA Inferred from Electronic Annotation more info
involved_in hindbrain development	IEA Inferred from Electronic Annotation more info
involved_in homeostatic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mesodermal cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast fate commitment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cartilage development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in primary miRNA processing	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in ureteric bud development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SMAD protein complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
part_of heteromeric SMAD protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heteromeric SMAD protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of homomeric SMAD protein complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mothers against decapentaplegic homolog 1

Names: MAD, mothers against decapentaplegic homolog 1; Mad-related protein 1; SMAD, mothers against DPP homolog 1; TGF-beta signaling protein 1; mothers against DPP homolog 1; transforming growth factor-beta signaling protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042284.1 RefSeqGene

Range

5055..82378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001003688.1 → NP_001003688.1 mothers against decapentaplegic homolog 1

See identical proteins and their annotated locations for NP_001003688.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

BC001878, BE644607, BI772689, BI792941, CB956339, U59912

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Related

ENSP00000377652.2, ENST00000394092.6

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354811.1 → NP_001341740.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (3) represents the longest transcript. All eight variants encode the same protein.

Source sequence(s)

AC093796

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354812.1 → NP_001341741.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

AC093796

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354813.1 → NP_001341742.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

AC093796

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354814.1 → NP_001341743.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

AC093796

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354816.1 → NP_001341745.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

AC093796

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_001354817.1 → NP_001341746.1 mothers against decapentaplegic homolog 1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

AC093796, AK293055

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Related

ENSP00000426568.1, ENST00000515385.1

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
NM_005900.3 → NP_005891.1 mothers against decapentaplegic homolog 1

See identical proteins and their annotated locations for NP_005891.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All eight variants encode the same protein.

Source sequence(s)

BC001878, BE644607, BI772689, BI792941, BQ962660, CB956339, U59423

Consensus CDS

CCDS3765.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Related

ENSP00000305769.4, ENST00000302085.9

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

145480770..145559176

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047415690.1 → XP_047271646.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_011531964.3 → XP_011530266.1 mothers against decapentaplegic homolog 1 isoform X1

See identical proteins and their annotated locations for XP_011530266.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
XM_047415688.1 → XP_047271644.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_011531962.3 → XP_011530264.1 mothers against decapentaplegic homolog 1 isoform X1

See identical proteins and their annotated locations for XP_011530264.1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Conserved Domains (3) summary

cd10490
Location:9 → 132

MH1_SMAD_1_5_9; N-terminal Mad Homology 1 (MH1) domain in SMAD1, SMAD5 and SMAD9 (also known as SMAD8)

cd10497
Location:265 → 465

MH2_SMAD_1_5_9; C-terminal Mad Homology 2 (MH2) domain in SMAD1, SMAD5 and SMAD9

PRK10263
Location:133 → 244

PRK10263; DNA translocase FtsK; Provisional
XM_047415691.1 → XP_047271647.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_047415689.1 → XP_047271645.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

148798276..148874991

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054350026.1 → XP_054206001.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350028.1 → XP_054206003.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350022.1 → XP_054205997.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350023.1 → XP_054205998.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350025.1 → XP_054206000.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350027.1 → XP_054206002.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8
XM_054350024.1 → XP_054205999.1 mothers against decapentaplegic homolog 1 isoform X1

UniProtKB/Swiss-Prot

A8KAJ0, D3DNZ9, Q15797, Q16636, Q9UFT8