Ppih peptidylprolyl isomerase H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppihprovided by RGD
Official Full Name: peptidylprolyl isomerase Hprovided by RGD
Primary source: RGD:1564921
See related: EnsemblRapid:ENSRNOG00000008489 AllianceGenome:RGD:1564921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564921
Summary: Predicted to enable cyclosporin A binding activity; peptidyl-prolyl cis-trans isomerase activity; and ribonucleoprotein complex binding activity. Predicted to be involved in positive regulation of viral genome replication and protein folding. Predicted to be located in nuclear speck. Predicted to be part of U4/U6 snRNP and U4/U6 x U5 tri-snRNP complex. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human PPIH (peptidylprolyl isomerase H). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 105.4), Spleen (RPKM 64.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (138191624..138209625, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (132906324..132924341, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (138343934..138361743, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138343 (e-PCR)
- UniSTS:220430

D5Got61 (e-PCR)
- UniSTS:115639

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of U4/U6 snRNP	ISO Inferred from Sequence Orthology more info
part_of U4/U6 x U5 tri-snRNP complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase H

Names: peptidylprolyl isomerase H (cyclophilin H)

NP_001386382.1

EC 5.2.1.8

XP_006238833.2

EC 5.2.1.8

XP_006238834.2

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399453.1 → NP_001386382.1 peptidyl-prolyl cis-trans isomerase H

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I5ZMT9, A6JZN2

Related

ENSRNOP00000088556.2, ENSRNOT00000108155.2

Conserved Domains (1) summary

cl00197
Location:8 → 177

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

138191624..138209625 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238771.5 → XP_006238833.2 peptidyl-prolyl cis-trans isomerase H isoform X1

UniProtKB/TrEMBL

A0A8I5ZMT9, A0A8I6A6F0, A6JZN2

Conserved Domains (1) summary

cl00197
Location:8 → 177

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
XM_006238772.5 → XP_006238834.2 peptidyl-prolyl cis-trans isomerase H isoform X1

UniProtKB/TrEMBL

A0A8I5ZMT9, A0A8I6A6F0, A6JZN2

Conserved Domains (1) summary

cl00197
Location:8 → 177

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...