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    phzM phenazine-specific methyltransferase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880514, updated on 24-Aug-2024

    Summary

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    Gene symbol
    phzM
    Gene description
    phenazine-specific methyltransferase
    Locus tag
    PA4209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (4712095..4713099, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene resistance-nodulation-cell division (RND) efflux membrane fusion protein Neighboring gene resistance-nodulation-cell division (RND) efflux transporter Neighboring gene hypothetical protein Neighboring gene phenazine biosynthesis protein Neighboring gene phenazine biosynthesis protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin. Prince LR, et al. J Immunol, 2008 Mar 1. PMID 18292577, Free PMC Article
    2. The purification, crystallization and preliminary structural characterization of PhzM, a phenazine-modifying methyltransferase from Pseudomonas aeruginosa. Gohain N, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Sep 1. PMID 16946471, Free PMC Article
    3. Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa. Huang J, et al. Appl Environ Microbiol, 2012 Jul. PMID 22562990, Free PMC Article
    4. Structural and functional analysis of the pyocyanin biosynthetic protein PhzM from Pseudomonas aeruginosa. Parsons JF, et al. Biochemistry, 2007 Feb 20. PMID 17253782, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crc protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis.
      Title: Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.
    2. Pyocyanin induces apoptosis by engagement of lysosomal pathways of cell death, which may be a pathological mechanism to which neutrophils are particularly susceptible.
      Title: Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.
    3. PhzM has been purified and crystallized; PhzM catalyzes the reaction in the proposed pathway for synthesis of the antibiotic pigment pyocyanin from phenazine-1-carboxylate.
      Title: The purification, crystallization and preliminary structural characterization of PhzM, a phenazine-modifying methyltransferase from Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenazine-specific methyltransferase
    NP_252898.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4712095..4713099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252898.1 phenazine-specific methyltransferase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252898.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2Z4NBT6, A0A6B9PAW2
      Conserved Domains (2) summary
      cl06920
      Location:12 → 90
      dimerization2; dimerization domain
      cl17173
      Location:110 → 315
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HWH2.1

    Gene LinkOut

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    Research Materials