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    ppkA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879361, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ppkA
    Primary source
    PseudoCap:PA0074
    Locus tag
    PA0074
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (87000..90098, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ABC transporter ATP-binding protein Neighboring gene serine/threonine phosphatase Neighboring gene hypothetical protein Neighboring gene type VI secretion protein IcmF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel serine/threonine protein kinase homologue of Pseudomonas aeruginosa is specifically inducible within the host infection site and is required for full virulence in neutropenic mice. Wang J, et al. J Bacteriol, 1998 Dec. PMID 9852028, Free PMC Article
    2. Serine/threonine protein kinase PpkA contributes to the adaptation and virulence in Pseudomonas aeruginosa. Pan J, et al. Microb Pathog, 2017 Dec. PMID 29038052
    3. TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa. Hsu F, et al. Mol Microbiol, 2009 Jun. PMID 19400797, Free PMC Article
    4. A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence. Goldová J, et al. BMC Genomics, 2011 Aug 31. PMID 21880152, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the mutant strain lacking ppkA exhibited a significant decrease of biofilm formation and pyocyanin production, less tolerance to oxidative and osmotic stresses, inefficient invasion of host cells and a reduction of bacterial virulence
      Title: Serine/threonine protein kinase PpkA contributes to the adaptation and virulence in Pseudomonas aeruginosa.
    2. Oxidative and osmotic stress resistance of P. aeruginosa is affected by the pppA-ppkA mutation. pppA-ppkA mutants are more sensitive to macrophage-mediated killing than the wild-type strain.
      Title: A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence.
    3. PpkA autophosphorylation and dimerization contribute to triggering the type VI secretion system.
      Title: TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine protein kinase PpkA
    NP_248764.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      87000..90098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_248764.1 serine/threonine protein kinase PpkA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_248764.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I758
      Conserved Domains (2) summary
      cd00198
      Location:616 → 797
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cd14014
      Location:7 → 261
      STKc_PknB_like; Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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