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    algU RNA polymerase sigma factor AlgU [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882125, updated on 11-Sep-2024

    Summary

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    Gene symbol
    algU
    Gene description
    RNA polymerase sigma factor AlgU
    Locus tag
    PA0762
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (831301..831882)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene L-aspartate oxidase Neighboring gene sigma factor AlgU negative regulator MucA Neighboring gene sigma factor AlgU regulator MucB Neighboring gene positive regulator for alginate biosynthesis MucC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The alternative sigma factor AlgT represses Pseudomonas aeruginosa flagellum biosynthesis by inhibiting expression of fleQ. Tart AH, et al. J Bacteriol, 2005 Dec. PMID 16291668, Free PMC Article
    2. The algT (algU) gene of Pseudomonas aeruginosa, a key regulator involved in alginate biosynthesis, encodes an alternative sigma factor (sigma E). Hershberger CD, et al. Proc Natl Acad Sci U S A, 1995 Aug 15. PMID 7644517, Free PMC Article
    3. Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT. Wozniak DJ, et al. J Bacteriol, 1994 Oct. PMID 7928961, Free PMC Article
    4. Microbial pathogenesis in cystic fibrosis: co-ordinate regulation of heat-shock response and conversion to mucoidy in Pseudomonas aeruginosa. Schurr MJ, et al. Mol Microbiol, 1997 Apr. PMID 9159526
    5. Control of Pseudomonas aeruginosa algZ expression by the alternative sigma factor AlgT. Wozniak DJ, et al. J Bacteriol, 2003 Dec. PMID 14645293, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
      Title: Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
    2. Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.
      Title: Overproduction of the AlgT Sigma Factor Is Lethal to Mucoid Pseudomonas aeruginosa.
    3. The structures reveal the molecular basis for MucA recognition by MucB in the periplasm and AlgU in the cytoplasm, thus providing an important step in understanding the mechanisms that regulate a key signal transduction pathway involved in P. aeruginosa pathogenesis.
      Title: Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa.
    4. AlgU controls rsmA transcription and is responsible for RsmA activity in mucA mutant strains.
      Title: Pseudomonas aeruginosa AlgU Contributes to Posttranscriptional Activity by Increasing rsmA Expression in a mucA22 Strain.
    5. In the current study, authors mapped the mucE transcriptional start site, and determined that P(mucE) activity was dependent on AlgU.
      Title: Expression of mucoid induction factor MucE is dependent upon the alternate sigma factor AlgU in Pseudomonas aeruginosa.
    6. Alginate biosynthesis in Pseudomonas aeruginosa is a highly regulated by algU and mucA genes.
      Title: Different mutations in mucA gene of Pseudomonas aeruginosa mucoid strains in cystic fibrosis patients and their effect on algU gene expression.
    7. AlgT, AlgU and AlgO positively regulate alginate production.
      Title: A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and algT/U activity results in the loss of alginate production.
    8. Data show that P. aeruginosa cultured in low shear modelled microgravity exhibit increased alginate production and upregulation of AlgU-controlled transcripts, including those encoding stress-related proteins.
      Title: Response of Pseudomonas aeruginosa PAO1 to low shear modelled microgravity involves AlgU regulation.
    9. The algU mutant of P. aeruginosa PAO1 (PAOU) showed a dramatic impairment in biofilm formation under dynamic conditions; PAOU was defective both in cell attachment to glass and in development of robust, shear-resistant biofilms.
      Title: The sigma factor AlgU plays a key role in formation of robust biofilms by nonmucoid Pseudomonas aeruginosa.
    10. Sigma 22 is controlled post-translationally by proteolysis and the sigma 22 regulon during cell wall stress.
      Title: Use of cell wall stress to characterize sigma 22 (AlgT/U) activation by regulated proteolysis and its regulon in Pseudomonas aeruginosa.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables sigma factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to cell envelope stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell adhesion involved in single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cellular response to heat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytosolic DNA-directed RNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA polymerase sigma factor AlgU
    NP_249453.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      831301..831882
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249453.1 RNA polymerase sigma factor AlgU [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249453.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A2SVT4
      Conserved Domains (1) summary
      PRK11923
      Location:1 → 193
      algU; RNA polymerase sigma factor AlgU; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06198.1

    Gene LinkOut

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    Research Materials