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    iscR HTH-type transcriptional regulator [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879919, updated on 24-Aug-2024

    Summary

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    Gene symbol
    iscR
    Gene description
    HTH-type transcriptional regulator
    Locus tag
    PA3815
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (4272165..4272656, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene scaffold protein Neighboring gene cysteine desulfurase Neighboring gene O-acetylserine synthase Neighboring gene methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of the Pseudomonas aeruginosa iron-sulfur cluster assembly pathway by binding of IscR to multiple sites. Saninjuk K, et al. PLoS One, 2019. PMID 31251744, Free PMC Article
    2. The iron-sulphur cluster biosynthesis regulator IscR contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa. Romsang A, et al. PLoS One, 2014. PMID 24466226, Free PMC Article
    3. Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation. Somprasong N, et al. J Bacteriol, 2012 Aug. PMID 22609922, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P. aeruginosa IscR as it contributes to the roles of an [Fe-S] cluster in several biologically important cellular activities.[IscR]
      Title: Transcriptional regulation of the Pseudomonas aeruginosa iron-sulfur cluster assembly pathway by binding of IscR to multiple sites.
    2. IscR is a transcriptional regulator of the isc operon and contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa.
      Title: The iron-sulphur cluster biosynthesis regulator IscR contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa.
    3. Altogether, Pseudomonas aeruginosa tpx is a novel member of the IscR regulon and plays a primary role in protecting the bacteria from submillimolar concentrations of H(2)O(2).
      Title: Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    HTH-type transcriptional regulator
    NP_252504.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4272165..4272656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252504.1 HTH-type transcriptional regulator [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252504.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9HXI7
      Conserved Domains (1) summary
      TIGR02010
      Location:1 → 135
      IscR; iron-sulfur cluster assembly transcription factor IscR
    Nucleotide Protein
    Heading Accession and Version

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