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    PA4608 hypothetical protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881102, updated on 24-Aug-2024

    Summary

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    Gene symbol
    PA4608
    Gene description
    hypothetical protein
    Locus tag
    PA4608
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5166900..5167277)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene DNA repair protein RadA Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses. Wei Q, et al. Appl Environ Microbiol, 2019 Nov 1. PMID 31444209, Free PMC Article
    2. Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate. Shin JS, et al. Protein Sci, 2011 Feb. PMID 21280119, Free PMC Article
    3. NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein. Ramelot TA, et al. Proteins, 2007 Feb 1. PMID 17096419
    4. Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP. Zhu Y, et al. Acta Crystallogr D Struct Biol, 2017 Aug 1. PMID 28777083
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclic-di-GMP (c-di-GMP) is an important second messenger involved in the regulation of biofilm formation. Among 40 c-di-GMP metabolizing genes, 5 have well-conserved phylogenetic distribution and invariable expression profiles, suggesting that there are enzymes required for the basal level of c-di-GMP in P. aeruginosa.
      Title: Diguanylate Cyclases and Phosphodiesterases Required for Basal-Level c-di-GMP in Pseudomonas aeruginosa as Revealed by Systematic Phylogenetic and Transcriptomic Analyses.
    2. Recently, a single-domain PilZ protein, MapZ (PA4608), was identified to inhibit the activity of the methyltransferase CheR1. Here, crystal structures of the C-terminal domain of CheR1 containing S-adenosylhomocysteine and of CheR1 in complex with c-di-GMP-bound MapZ are reported.
      Title: Structural basis for the regulation of chemotaxis by MapZ in the presence of c-di-GMP.
    3. Determined the solution structure of c-di-GMP bound PA4608. We found that PA4608 undergoes conformational changes to expose the c-di-GMP binding site by ejection of the C-terminal 3(10) helix.
      Title: Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate.
    4. The monomeric core of PA4608 has a 6-stranded antiparallel beta barrel flanked by 3 helices. Conserved surface residues of PA4608 homologs show c-di-GMP binding site is at 1 end of the barrel & has residues in the helices & the unstructured N-terminus.
      Title: NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c-di-GMP binding protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    hypothetical protein
    NP_253298.1
    • 'Product name confidence: class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences)'

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5166900..5167277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253298.1 hypothetical protein PA4608 [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253298.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HVI1
      Conserved Domains (1) summary
      pfam07238
      Location:7 → 103
      PilZ; PilZ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HVI1.1

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