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    algR alginate biosynthesis regulatory protein AlgR [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877674, updated on 11-Sep-2024

    Summary

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    Gene symbol
    algR
    Gene description
    alginate biosynthesis regulatory protein AlgR
    Locus tag
    PA5261
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5922544..5923290, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene uroporphyrinogen-III synthase Neighboring gene porphobilinogen deaminase Neighboring gene alginate biosynthesis protein AlgZ/FimS Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa. Kong W, et al. Nucleic Acids Res, 2015 Sep 30. PMID 26206672, Free PMC Article
    2. Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene. Deretic V, et al. Nucleic Acids Res, 1987 Jun 11. PMID 3108855, Free PMC Article
    3. Pseudomonas aeruginosa AlgR phosphorylation modulates rhamnolipid production and motility. Okkotsu Y, et al. J Bacteriol, 2013 Dec. PMID 24097945, Free PMC Article
    4. The transcriptional regulator AlgR is essential for Pseudomonas aeruginosa pathogenesis. Lizewski SE, et al. Infect Immun, 2002 Nov. PMID 12379685, Free PMC Article
    5. Pseudomonas aeruginosa AlgR regulates type IV pilus biosynthesis by activating transcription of the fimU-pilVWXY1Y2E operon. Belete B, et al. J Bacteriol, 2008 Mar. PMID 18178737, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results show that the AlgR phosphorylation state can directly, as well as indirectly, modulate the expression of iron acquisition genes that may ultimately impact the ability of Pseudomonas aeruginosa to establish and maintain an infection.
      Title: Pseudomonas aeruginosa AlgR Phosphorylation Status Differentially Regulates Pyocyanin and Pyoverdine Production.
    2. In conclusion, this study for the first time indicates that AlgR directly binds to rsmZ to regulates the expression of lipA via regulating transcription of rsmZ, and mainly regulates the expression of lipA at transcriptional level in P. protegens Pf-5.
      Title: The Pseudomonas transcriptional regulator AlgR controls LipA expression via the noncoding RNA RsmZ in Pseudomonas protegens Pf-5.
    3. AlgR controls the levels of c-di-GMP synthesis via direct regulation of mucR, which encodes a diguanylate cyclase.
      Title: ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa.
    4. AlgZ and algR transcription involves multiple factors at multiple start sites that control individual gene expression.
      Title: Expression analysis of the Pseudomonas aeruginosa AlgZR two-component regulatory system.
    5. These results indicate that phosphorylated AlgR-P has increased affinity for the rhlA promoter and is required for the coordinate activation of twitching motility, rhamnolipid production, and swarming motility in P. aeruginosa.
      Title: Pseudomonas aeruginosa AlgR phosphorylation modulates rhamnolipid production and motility.
    6. Strains lacking AlgR or the putative AlgR sensor AlgZ produced significantly less hydrogen cyanide than did a nonmucoid isogenic parent.
      Title: Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner.
    7. Findings indicate that AlgR is essential for proper pilin localization and that phosphorylation of AlgR results in direct activation of the fimU-pilVWXY1Y2E operon, which is required for the assembly and export of a functional type IV pilus.
      Title: Pseudomonas aeruginosa AlgR regulates type IV pilus biosynthesis by activating transcription of the fimU-pilVWXY1Y2E operon.
    8. AlgR specifically represses the Rhl quorum-sensing system during biofilm growth.
      Title: Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type IV pilus-dependent motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alginate biosynthesis regulatory protein AlgR
    NP_253948.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5922544..5923290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253948.1 alginate biosynthesis regulatory protein AlgR [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253948.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P26275
      Conserved Domains (1) summary
      COG3279
      Location:1 → 248
      LytT; DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26275.1

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