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    crc catabolite repression control protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878037, updated on 11-Sep-2024

    Summary

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    Gene symbol
    crc
    Gene description
    catabolite repression control protein
    Locus tag
    PA5332
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (6002121..6002900)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene orotate phosphoribosyltransferase Neighboring gene hypothetical protein Neighboring gene ribonuclease PH

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of catabolite repression control mutants of Pseudomonas aeruginosa PAO. Wolff JA, et al. J Bacteriol, 1991 Aug. PMID 1906870, Free PMC Article
    2. The global regulator Crc orchestrates the metabolic robustness underlying oxidative stress resistance in Pseudomonas aeruginosa. Corona F, et al. Environ Microbiol, 2019 Mar. PMID 30411469
    3. The global carbon metabolism regulator Crc is a component of a signal transduction pathway required for biofilm development by Pseudomonas aeruginosa. O'Toole GA, et al. J Bacteriol, 2000 Jan. PMID 10629189, Free PMC Article
    4. The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Linares JF, et al. Environ Microbiol, 2010 Dec. PMID 20626455
    5. The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity. Milojevic T, et al. PLoS One, 2013. PMID 23717639, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa.
      Title: Stabilization of Hfq-mediated translational repression by the co-repressor Crc in Pseudomonas aeruginosa.
    2. Crc orchestrates the overall response of P. aeruginosa to oxidative stress
      Title: The global regulator Crc orchestrates the metabolic robustness underlying oxidative stress resistance in Pseudomonas aeruginosa.
    3. We describe high-resolution cryo-EM structures of the assembly of Hfq and Crc bound to the translation initiation site of a target mRNA. The core of the assembly is formed through interactions of two cognate RNAs, two Hfq hexamers and a Crc pair.
      Title: Architectural principles for Hfq/Crc-mediated regulation of gene expression.
    4. It has been shown that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA. Through these interactions, Crc enhances the stability of Hfq/Crc/RNA complexes, which can explain its facilitating role in Hfq-mediated translational repression.
      Title: Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.
    5. This study therefore uncovers a novel posttranscriptional regulatory cascade, Crc-Hfq/Lon/RhlI, for the regulation of rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
      Title: The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
    6. Crc protein from P. aeruginosa does not display DNase activity, nor does it bind to previously identified RNA substrates.
      Title: The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity.
    7. Crc may exert multifaceted control on the type III secretion system through various pathways, which may serve to fine-tune this virulence mechanism in response to environmental changes and nutrient sources.
      Title: The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa.
    8. Crc protein repressed the formation of the blue pigment pyocyanin in response to a preferred carbon source (succinate) by interacting with phzM mRNA, which encodes a key enzyme in pyocyanin biosynthesis.
      Title: Catabolite repression control of pyocyanin biosynthesis at an intersection of primary and secondary metabolism in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within quorum sensing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of carbon utilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catabolite repression control protein
    NP_254019.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      6002121..6002900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_254019.1 catabolite repression control protein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_254019.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XDB0, Q51380
      Conserved Domains (1) summary
      cd10281
      Location:1 → 253
      Nape_like_AP-endo; Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases
    Nucleotide Protein
    Heading Accession and Version

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