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    Stt3b STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 68292, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stt3bprovided by MGI
    Official Full Name
    STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1915542
    See related
    Ensembl:ENSMUSG00000032437 AllianceGenome:MGI:1915542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Simp; 1300006C19Rik
    Summary
    Predicted to enable dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in several processes, including ERAD pathway; co-translational protein modification; and protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ix. Orthologous to human STT3B (STT3 oligosaccharyltransferase complex catalytic subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 118.7), genital fat pad adult (RPKM 49.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stt3b in Genome Data Viewer
    Location:
    9 F3; 9 67.71 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (115071538..115139536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (115242470..115310468, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 10 Neighboring gene predicted gene, 53513 Neighboring gene predicted gene, 26962 Neighboring gene stathmin 1, related sequence 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:115217576-115217877 Neighboring gene STARR-positive B cell enhancer ABC_E1395 Neighboring gene RIKEN cDNA 4930428G15 gene Neighboring gene STARR-positive B cell enhancer mm9_chr9:115259880-115260181 Neighboring gene STARR-seq mESC enhancer starr_25403 Neighboring gene STARR-seq mESC enhancer starr_25404 Neighboring gene predicted gene, 30762

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in co-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in co-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoprotein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in post-translational protein modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in post-translational protein modification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein N-linked glycosylation via asparagine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to unfolded protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of oligosaccharyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of oligosaccharyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of oligosaccharyltransferase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
    Names
    B6dom1 antigen
    oligosaccharyl transferase subunit STT3B
    source of immunodominant MHC-associated peptides
    NP_077184.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024222.3NP_077184.2  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

      See identical proteins and their annotated locations for NP_077184.2

      Status: VALIDATED

      Source sequence(s)
      AI852345, AK152899, BC052433
      Consensus CDS
      CCDS23599.1
      UniProtKB/Swiss-Prot
      Q3TDQ1, Q7TT24, Q921E3, Q99LL0, Q9D2V2
      UniProtKB/TrEMBL
      A0A0R4J0D3
      Related
      ENSMUSP00000035010.9, ENSMUST00000035010.10
      Conserved Domains (1) summary
      pfam02516
      Location:68560
      STT3; Oligosaccharyl transferase STT3 subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      115071538..115139536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)