U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gadl1 glutamate decarboxylase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 73748, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gadl1provided by MGI
    Official Full Name
    glutamate decarboxylase-like 1provided by MGI
    Primary source
    MGI:MGI:1920998
    See related
    Ensembl:ENSMUSG00000056880 AllianceGenome:MGI:1920998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADC; CSADC; 1110027M19Rik
    Summary
    Predicted to enable carboxy-lyase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be active in cytoplasm. Orthologous to human GADL1 (glutamate decarboxylase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gadl1 in Genome Data Viewer
    Location:
    9 F3; 9 68.25 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (115713739..115905244)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (115884671..116076176)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:115550000-115550206 Neighboring gene STARR-positive B cell enhancer ABC_E9127 Neighboring gene RIKEN cDNA D330037F02 gene Neighboring gene predicted gene, 39448 Neighboring gene STARR-seq mESC enhancer starr_25408 Neighboring gene STARR-positive B cell enhancer mm9_chr9:115619212-115619513 Neighboring gene STARR-seq mESC enhancer starr_25409 Neighboring gene STARR-seq mESC enhancer starr_25410 Neighboring gene STARR-seq mESC enhancer starr_25412 Neighboring gene predicted gene, 31234 Neighboring gene predicted gene 16142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:115986132-115986403 Neighboring gene STARR-positive B cell enhancer ABC_E10588 Neighboring gene predicted gene, 31014 Neighboring gene vaccinia related kinase 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25413 Neighboring gene transforming growth factor, beta receptor II Neighboring gene STARR-seq mESC enhancer starr_25414 Neighboring gene predicted gene, 31292

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aspartate 1-decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sulfinoalanine decarboxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in carboxylic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    acidic amino acid decarboxylase GADL1
    Names
    aspartate 1-decarboxylase
    cysteine sulfinic acid decarboxylase
    glutamate decarboxylase-like protein 1
    NP_001382689.1
    NP_082914.1
    XP_006512382.1
    XP_036011234.1
    XP_036011235.1
    XP_036011236.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395760.1NP_001382689.1  acidic amino acid decarboxylase GADL1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC131777, AC133169, AC167467
      UniProtKB/Swiss-Prot
      Q80WP8, Q9CTD2
      UniProtKB/TrEMBL
      K4DI69
      Related
      ENSMUSP00000077694.7, ENSMUST00000069651.14
      Conserved Domains (1) summary
      cd06450
      Location:118518
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    2. NM_028638.1NP_082914.1  acidic amino acid decarboxylase GADL1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131777, AK003937, BC052327
      Consensus CDS
      CCDS52954.1
      UniProtKB/Swiss-Prot
      Q80WP8, Q9CTD2
      UniProtKB/TrEMBL
      A0A8Q0QWL6
      Related
      ENSMUSP00000159481.1, ENSMUST00000240548.1
      Conserved Domains (1) summary
      cd06450
      Location:98498
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      115713739..115905244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512319.4XP_006512382.1  acidic amino acid decarboxylase GADL1 isoform X2

      See identical proteins and their annotated locations for XP_006512382.1

      UniProtKB/Swiss-Prot
      Q80WP8, Q9CTD2
      Conserved Domains (1) summary
      cd06450
      Location:114514
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    2. XM_036155341.1XP_036011234.1  acidic amino acid decarboxylase GADL1 isoform X2

      UniProtKB/Swiss-Prot
      Q80WP8, Q9CTD2
      Related
      ENSMUSP00000113240.3, ENSMUST00000121770.3
      Conserved Domains (1) summary
      cd06450
      Location:114514
      DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...
    3. XM_036155342.1XP_036011235.1  acidic amino acid decarboxylase GADL1 isoform X3

      UniProtKB/Swiss-Prot
      Q80WP8, Q9CTD2
      Conserved Domains (1) summary
      cl18945
      Location:78436
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
    4. XM_036155343.1XP_036011236.1  acidic amino acid decarboxylase GADL1 isoform X4

      Conserved Domains (1) summary
      cl18945
      Location:27282
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...