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    Rbms3 RNA binding motif, single stranded interacting protein [ Mus musculus (house mouse) ]

    Gene ID: 207181, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbms3provided by MGI
    Official Full Name
    RNA binding motif, single stranded interacting proteinprovided by MGI
    Primary source
    MGI:MGI:2444477
    See related
    Ensembl:ENSMUSG00000039607 AllianceGenome:MGI:2444477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6720477E09Rik; 8430436O14Rik
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within positive regulation of translation. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and olfactory epithelium. Orthologous to human RBMS3 (RNA binding motif single stranded interacting protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 4.8), bladder adult (RPKM 3.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rbms3 in Genome Data Viewer
    Location:
    9 F3; 9 68.78 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (116401814..117869900, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (116572746..117629913, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25427 Neighboring gene STARR-seq mESC enhancer starr_25433 Neighboring gene predicted gene, 31559 Neighboring gene STARR-seq mESC enhancer starr_25435 Neighboring gene predicted gene, 39449 Neighboring gene STARR-seq mESC enhancer starr_25437 Neighboring gene STARR-seq mESC enhancer starr_25439 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:117063131-117063298 Neighboring gene STARR-seq mESC enhancer starr_25440 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene VISTA enhancer mm1697 Neighboring gene STARR-seq mESC enhancer starr_25441 Neighboring gene predicted gene, 39452 Neighboring gene STARR-seq mESC enhancer starr_25443 Neighboring gene STARR-seq mESC enhancer starr_25444 Neighboring gene predicted gene, 17396 Neighboring gene STARR-seq mESC enhancer starr_25445 Neighboring gene predicted gene, 39451 Neighboring gene STARR-seq mESC enhancer starr_25446 Neighboring gene STARR-seq mESC enhancer starr_25447 Neighboring gene STARR-seq mESC enhancer starr_25448 Neighboring gene STARR-seq mESC enhancer starr_25449 Neighboring gene predicted gene, 39450 Neighboring gene STARR-seq mESC enhancer starr_25450 Neighboring gene predicted gene, 26614 Neighboring gene predicted gene, 50606 Neighboring gene STARR-positive B cell enhancer ABC_E3864 Neighboring gene STARR-positive B cell enhancer ABC_E2921 Neighboring gene STARR-positive B cell enhancer mm9_chr9:117962449-117962749 Neighboring gene zinc finger, CW type with PWWP domain 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118059288-118059397 Neighboring gene 5-azacytidine induced gene 2 Neighboring gene predicted gene, 17399 Neighboring gene C-X9-C motif containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC118437

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    RNA-binding motif, single-stranded-interacting protein 3
    Names
    RNA-binding protein RBMS3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172121.1NP_001165592.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 4

      See identical proteins and their annotated locations for NP_001165592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest protein (isoform 4).
      Source sequence(s)
      AC138313, AK046197, BE136226
      Consensus CDS
      CCDS57712.1
      UniProtKB/TrEMBL
      A0A6I8MX12
      Related
      ENSMUSP00000131371.3, ENSMUST00000164018.9
      Conserved Domains (2) summary
      cd12475
      Location:183270
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:100183
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_001172122.1NP_001165593.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001165593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 5' UTR and in the coding region, compared to variant 4. The resulting protein (isoform 3) has multiple differences when it is compared to isoform 4.
      Source sequence(s)
      AC138313, AK030609, AK041098, BE136226
      Consensus CDS
      CCDS52955.1
      UniProtKB/Swiss-Prot
      Q8BWL5
      Related
      ENSMUSP00000107402.4, ENSMUST00000111772.10
      Conserved Domains (2) summary
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. NM_001172123.1NP_001165594.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001165594.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses different segments for its 5' UTR and 5' coding region, and contains an alternate exon in its 3' coding region, compared to variant 4. The resulting protein (isoform 1) has multiple differences when it is compared to isoform 4.
      Source sequence(s)
      AC138313, AK041098, AK052196, BE136226
      Consensus CDS
      CCDS52957.1
      UniProtKB/Swiss-Prot
      Q2VPR0, Q8BL73, Q8BLW6, Q8BMA7, Q8BMB5, Q8BML0, Q8BMN1, Q8BWL5
      Related
      ENSMUSP00000107403.4, ENSMUST00000111773.10
      Conserved Domains (2) summary
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. NM_001172124.1NP_001165595.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 5

      See identical proteins and their annotated locations for NP_001165595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' UTR and in the coding region, one of which changes the reading frame, compared to variant 4. The resulting protein (isoform 5) has multiple differences including a distinct and shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AC138313, AK033005, AK041098, BE136226
      Consensus CDS
      CCDS52956.1
      UniProtKB/Swiss-Prot
      Q8BWL5
      Related
      ENSMUSP00000133621.2, ENSMUST00000174868.8
      Conserved Domains (2) summary
      cd12472
      Location:52131
      RRM1_RBMS3; RNA recognition motif 1 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    5. NM_001172126.1NP_001165597.1  RNA-binding motif, single-stranded-interacting protein 3 isoform 6

      See identical proteins and their annotated locations for NP_001165597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences in the 5' UTR and in the coding region, one of which changes the reading frame, compared to variant 4. The resulting protein (isoform 6) has multiple differences including a distinct and shorter C-terminus when it is compared to isoform 4.
      Source sequence(s)
      AC138313, AK041098, BE136226
      Consensus CDS
      CCDS57711.1
      UniProtKB/TrEMBL
      Q8BKJ2
      Related
      ENSMUSP00000039706.8, ENSMUST00000044901.14
      Conserved Domains (2) summary
      cd12472
      Location:52131
      RRM1_RBMS3; RNA recognition motif 1 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    6. NM_178660.4NP_848775.2  RNA-binding motif, single-stranded-interacting protein 3 isoform 3

      See identical proteins and their annotated locations for NP_848775.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses different segments for its 5' UTR and 5' coding region, compared to variant 4. The resulting protein (isoform 3) has a shorter and distinct N-terminus when it is compared to isoform 4.
      Source sequence(s)
      AC138313, AK030478, AK041098, BC108402, BE136226
      Consensus CDS
      CCDS40798.1
      UniProtKB/Swiss-Prot
      Q8BWL5
      Related
      ENSMUSP00000066735.8, ENSMUST00000068962.14
      Conserved Domains (2) summary
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      116401814..117869900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154757.1XP_036010650.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X1

      Conserved Domains (2) summary
      cd12475
      Location:151238
      RRM2_RBMS3; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cd12472
      Location:69148
      RRM1_RBMS3; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
    2. XM_017313253.2XP_017168742.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X5

      UniProtKB/TrEMBL
      Q8BKJ2
      Conserved Domains (2) summary
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily
    3. XM_017313252.2XP_017168741.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X4

      UniProtKB/TrEMBL
      Q8BKJ2
      Conserved Domains (3) summary
      TIGR01645
      Location:78367
      half-pint; poly-U binding splicing factor, half-pint family
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_017313251.3XP_017168740.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X3

      Conserved Domains (2) summary
      cd12475
      Location:134221
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:51134
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_030244162.2XP_030100022.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X6

      Conserved Domains (2) summary
      cd12475
      Location:100187
      RRM2_RBMS3; RNA recognition motif 2 found in vertebrate RNA-binding motif, single-stranded-interacting protein 3 (RBMS3)
      cl17169
      Location:17100
      RRM_SF; RNA recognition motif (RRM) superfamily
    6. XM_036154758.1XP_036010651.1  RNA-binding motif, single-stranded-interacting protein 3 isoform X2

      Conserved Domains (2) summary
      pfam07496
      Location:1462
      zf-CW; CW-type Zinc Finger
      cl02554
      Location:82155
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...