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    Atp5f1d ATP synthase F1 subunit delta [ Mus musculus (house mouse) ]

    Gene ID: 66043, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp5f1dprovided by MGI
    Official Full Name
    ATP synthase F1 subunit deltaprovided by MGI
    Primary source
    MGI:MGI:1913293
    See related
    Ensembl:ENSMUSG00000003072 AllianceGenome:MGI:1913293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atp5d; 0610008F14Rik; 1500000I11Rik
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly and proton motive force-driven mitochondrial ATP synthesis. Predicted to act upstream of or within proton transmembrane transport. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 5. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in duodenum adult (RPKM 1424.1), adrenal adult (RPKM 1222.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp5f1d in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79974451..79981662)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80138698..80145828)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene strawberry notch 2 Neighboring gene STARR-seq mESC enhancer starr_27263 Neighboring gene STARR-seq mESC enhancer starr_27266 Neighboring gene serine/threonine kinase 11 Neighboring gene STARR-positive B cell enhancer ABC_E11444 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E1806 Neighboring gene STARR-seq mESC enhancer starr_27268 Neighboring gene STARR-seq mESC enhancer starr_27269 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79621397-79621506 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:79622453-79622640 Neighboring gene midnolin Neighboring gene STARR-positive B cell enhancer ABC_E2949 Neighboring gene cold inducible RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ATP5D Is a Potential Biomarker for Male Fertility. Wang YB, et al. Oxid Med Cell Longev, 2023. PMID 36686378, Free PMC Article
    2. Identification of a new Mpl-interacting protein, Atp5d. Liu H, et al. Mol Cell Biochem, 2014 Jun. PMID 24615392
    3. Role of the mitochondrial ATP synthase central stalk subunits γ and δ in the activity and assembly of the mammalian enzyme. Pecina P, et al. Biochim Biophys Acta Bioenerg, 2018 May. PMID 29499186
    4. Copy number variation modifies expression time courses. Chaignat E, et al. Genome Res, 2011 Jan. PMID 21084671, Free PMC Article
    5. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATP5D Is a Potential Biomarker for Male Fertility.
      Title: ATP5D Is a Potential Biomarker for Male Fertility.
    2. Both gamma and delta subunits silenced cells displayed decreased ATP synthase function - lowered rate of ADP-stimulated respiration, a two-fold increased sensitivity of respiration to inhibitor oligomycin, and impaired utilization of mitochondrial membrane potential for ADP phosphorylation.
      Title: Role of the mitochondrial ATP synthase central stalk subunits γ and δ in the activity and assembly of the mammalian enzyme.
    3. The interaction between Mpl and Atp5d was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro.
      Title: Identification of a new Mpl-interacting protein, Atp5d.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proton transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aerobic respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial proton-transporting ATP synthase complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proton transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of proton-transporting ATP synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting ATP synthase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase subunit delta, mitochondrial
    Names
    ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
    F-ATPase delta subunit
    NP_001334021.1
    NP_079589.2
    XP_017169541.1
    XP_030101070.1
    XP_030101071.1
    XP_030101072.1
    XP_030101073.1
    XP_036011835.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347092.2 → NP_001334021.1  ATP synthase subunit delta, mitochondrial isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC159999
      Consensus CDS
      CCDS83726.1
      UniProtKB/TrEMBL
      D3Z7S4
      Related
      ENSMUSP00000101005.2, ENSMUST00000105366.2
      Conserved Domains (1) summary
      cd12152
      Location:38 → 98
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    2. NM_025313.3 → NP_079589.2  ATP synthase subunit delta, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_079589.2

      Status: VALIDATED

      Source sequence(s)
      AC159999
      Consensus CDS
      CCDS24010.1
      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Related
      ENSMUSP00000003156.9, ENSMUST00000003156.15
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79974451..79981662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314052.3 → XP_017169541.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    2. XM_030245212.2 → XP_030101072.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    3. XM_030245213.2 → XP_030101073.1  ATP synthase subunit delta, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D3Z7S4
      Conserved Domains (1) summary
      cd12152
      Location:38 → 98
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    4. XM_036155942.1 → XP_036011835.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    5. XM_030245211.2 → XP_030101071.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    6. XM_030245210.2 → XP_030101070.1  ATP synthase subunit delta, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q9D3D9
      UniProtKB/TrEMBL
      Q4FK74, Q9D0J2, Q9DCZ0
      Related
      ENSMUSP00000101006.2, ENSMUST00000105367.8
      Conserved Domains (1) summary
      cd12152
      Location:38 → 162
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3D9.1 GenPept UniProtKB/Swiss-Prot:Q9D3D9

    Gene LinkOut

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