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    Fbxl16 F-box and leucine-rich repeat protein 16 [ Mus musculus (house mouse) ]

    Gene ID: 214931, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxl16provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 16provided by MGI
    Primary source
    MGI:MGI:2448488
    See related
    Ensembl:ENSMUSG00000025738 AllianceGenome:MGI:2448488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scirr1
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adrenal gland; gut; male reproductive gland or organ; and nervous system. Orthologous to human FBXL16 (F-box and leucine rich repeat protein 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 168.0), frontal lobe adult (RPKM 157.2) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl16 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26027435..26040236)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25808461..25821262)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 78 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25929287-25929470 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator Neighboring gene STARR-positive B cell enhancer ABC_E7500 Neighboring gene WD repeat domain 24 Neighboring gene jumonji domain containing 8 Neighboring gene microRNA 3082 Neighboring gene STIP1 homology and U-Box containing protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury. Liu T, et al. Exp Mol Med, 2007 Jun 30. PMID 17603280
    2. FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Araujo DJ, et al. Genes Dev, 2015 Oct 15. PMID 26494785, Free PMC Article
    3. F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Honarpour N, et al. Mol Cell Proteomics, 2014 Mar. PMID 24390425, Free PMC Article
    4. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Wang N, et al. Neuron, 2022 Oct 19. PMID 36265442, Free PMC Article
    5. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXL16 negatively regulates the activity of B55alpha-PP2A to modulate the genesis of FLK1+ progenitor cells.
      Title: F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage.
    2. SCIRR1 ise involved in the succeeding injury and/or repair processes of the injured spinal cord.
      Title: Identification and characterization of scirr1, a novel gene up-regulated after spinal cord injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164225.2 → NP_001157697.1  F-box/LRR-repeat protein 16 isoform 1

      See identical proteins and their annotated locations for NP_001157697.1

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      Consensus CDS
      CCDS50036.1
      UniProtKB/Swiss-Prot
      A2RT62
      UniProtKB/TrEMBL
      B2RPY3
      Related
      ENSMUSP00000048562.8, ENSMUST00000045692.9
      Conserved Domains (2) summary
      cd09293
      Location:201 → 413
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:220 → 243
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001379393.1 → NP_001366322.1  F-box/LRR-repeat protein 16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      UniProtKB/Swiss-Prot
      A2RT62
      UniProtKB/TrEMBL
      B2RPY3
      Conserved Domains (2) summary
      cd09293
      Location:201 → 413
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:220 → 243
      LRR_AMN1; leucine-rich repeat [structural motif]

    3. NM_001379394.1 → NP_001366323.1  F-box/LRR-repeat protein 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134908, AC159277
      Conserved Domains (3) summary
      cd09293
      Location:297 → 509
      AMN1; Antagonist of mitotic exit network protein 1
      PHA03247
      Location:31 → 193
      PHA03247; large tegument protein UL36; Provisional
      sd00034
      Location:316 → 339
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      26027435..26040236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2RT62.1 GenPept UniProtKB/Swiss-Prot:A2RT62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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