Mpi mannose phosphate isomerase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpiprovided by MGI
Official Full Name: mannose phosphate isomeraseprovided by MGI
Primary source: MGI:MGI:97075
See related: Ensembl:ENSMUSG00000032306 AllianceGenome:MGI:97075
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mpi1; Mpi-1; 1110002E17Rik
Summary: Enables mannose-6-phosphate isomerase activity. Involved in GDP-mannose biosynthetic process from glucose. Acts upstream of or within mannose to fructose-6-phosphate catabolic process. Is active in cytosol. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 49.7), large intestine adult (RPKM 32.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 31.05 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (57448744..57460095, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (57544260..57552812, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
Title: PMI-controlled mannose metabolism and glycosylation determines tissue tolerance and virus fitness.
Data indicate that reduced phosphomannose isomerase (MPI) alters mannose flux in hypomorphic mice.
Title: Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.
Phosphomannose isomerase activity and mRNA levels increased at 1 month, and the values in the ileum were lower than in jejunum.
Title: Ontogeny of D-mannose transport and metabolism in rat small intestine.
Data conclude that PMI-null cells can salvage mannose from both endogenous and external glycoconjugates via lysosomal and nonlysosomal degradation pathways.
Title: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.
Results suggest that mannose toxicity in phosphomannose isomerase(-/-) embryos is caused by mannose-6-P accumulation, which inhibits glucose metabolism and depletes intracellular ATP.
Title: Ablation of mouse phosphomannose isomerase (Mpi) causes mannose 6-phosphate accumulation, toxicity, and embryonic lethality.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mannose-6-phosphate isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannose-6-phosphate isomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables mannose-6-phosphate isomerase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannose-6-phosphate isomerase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GDP-mannose biosynthetic process from fructose-6-phosphate	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process from glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glycolytic process from mannose through fructose-6-phosphate	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within mannose to fructose-6-phosphate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannose to fructose-6-phosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mannose to fructose-6-phosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mannose-6-phosphate isomerase

Names: PMI; mannose phosphate isomerase 1; phosphohexomutase; phosphomannose isomerase

NP_080113.1

EC 5.3.1.8

XP_006510834.1

EC 5.3.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025837.2 → NP_080113.1 mannose-6-phosphate isomerase

See identical proteins and their annotated locations for NP_080113.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AK132777

Consensus CDS

CCDS40650.1

UniProtKB/Swiss-Prot

Q924M7

UniProtKB/TrEMBL

Q3V100, Q921Z9

Related

ENSMUSP00000034856.9, ENSMUST00000034856.15

Conserved Domains (2) summary

COG1482
Location:9 → 403

ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]

pfam01238
Location:6 → 381

PMI_typeI; Phosphomannose isomerase type I

RNA

NR_151692.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC164548

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

57448744..57460095 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006510771.4 → XP_006510834.1 mannose-6-phosphate isomerase isoform X1

Conserved Domains (1) summary

cl21464
Location:3 → 192

cupin_like; Conserved domain found in cupin and related proteins