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    Iqce IQ motif containing E [ Mus musculus (house mouse) ]

    Gene ID: 74239, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Iqceprovided by MGI
    Official Full Name
    IQ motif containing Eprovided by MGI
    Primary source
    MGI:MGI:1921489
    See related
    Ensembl:ENSMUSG00000036555 AllianceGenome:MGI:1921489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1023; 1700028P05Rik
    Summary
    Involved in positive regulation of transcription by RNA polymerase II; protein localization to motile cilium; and regulation of smoothened signaling pathway. Located in ciliary membrane and cytoplasmic side of plasma membrane. Part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.3), CNS E18 (RPKM 6.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iqce in Genome Data Viewer
    Location:
    5 G2; 5 79.2 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140648308..140688158, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140662553..140702403, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:141093710-141094027 Neighboring gene STARR-positive B cell enhancer ABC_E11729 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene tweety family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6392 Neighboring gene STARR-positive B cell enhancer ABC_E11307 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene predicted gene, 30745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, et al. Dev Cell, 2014 Mar 10. PMID 24582806, Free PMC Article
    2. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    IQ domain-containing protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347517.1 → NP_001334446.1  IQ domain-containing protein E isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC110253
      Consensus CDS
      CCDS84987.1
      UniProtKB/Swiss-Prot
      Q6PCQ0
      Related
      ENSMUSP00000077050.6, ENSMUST00000077890.12

    2. NM_028833.3 → NP_083109.2  IQ domain-containing protein E isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC110253
      Consensus CDS
      CCDS39358.1
      UniProtKB/Swiss-Prot
      Q6PCQ0, Q8CDZ1, Q9D9U3
      Related
      ENSMUSP00000045913.8, ENSMUST00000041783.14
      Conserved Domains (2) summary
      smart00015
      Location:553 → 573
      IQ; Calmodulin-binding motif
      pfam01486
      Location:399 → 476
      K-box; K-box region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      140648308..140688158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254853.1 → XP_030110713.1  IQ domain-containing protein E isoform X7

      Conserved Domains (2) summary
      COG1196
      Location:167 → 436
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:93 → 693
      CCDC158; Coiled-coil domain-containing protein 158

    2. XM_006504742.4 → XP_006504805.1  IQ domain-containing protein E isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:448 → 765
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:167 → 436
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036165559.1 → XP_036021452.1  IQ domain-containing protein E isoform X10

      Conserved Domains (3) summary
      PLN03209
      Location:469 → 708
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00015
      Location:451 → 471
      IQ; Calmodulin-binding motif
      COG1196
      Location:167 → 453
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_006504741.4 → XP_006504804.1  IQ domain-containing protein E isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:475 → 792
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:380 → 461
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_006504744.4 → XP_006504807.1  IQ domain-containing protein E isoform X5

      Conserved Domains (3) summary
      PLN03209
      Location:514 → 753
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00015
      Location:496 → 516
      IQ; Calmodulin-binding motif
      COG1196
      Location:212 → 498
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_006504745.4 → XP_006504808.1  IQ domain-containing protein E isoform X9

      Conserved Domains (2) summary
      smart00015
      Location:553 → 573
      IQ; Calmodulin-binding motif
      COG1196
      Location:212 → 481
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_006504740.4 → XP_006504803.1  IQ domain-containing protein E isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:493 → 805
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:212 → 565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    8. XM_006504739.4 → XP_006504802.1  IQ domain-containing protein E isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:493 → 810
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:212 → 565
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    9. XM_006504746.4 → XP_006504809.1  IQ domain-containing protein E isoform X14

      Conserved Domains (2) summary
      PHA03247
      Location:254 → 571
      PHA03247; large tegument protein UL36; Provisional
      TIGR02169
      Location:18 → 241
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    10. XM_030254857.1 → XP_030110717.1  IQ domain-containing protein E isoform X14

      Conserved Domains (2) summary
      PHA03247
      Location:254 → 571
      PHA03247; large tegument protein UL36; Provisional
      TIGR02169
      Location:18 → 241
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    11. XM_036165558.1 → XP_036021451.1  IQ domain-containing protein E isoform X8

      Conserved Domains (2) summary
      smart00015
      Location:496 → 516
      IQ; Calmodulin-binding motif
      COG1196
      Location:212 → 498
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    12. XM_030254859.2 → XP_030110719.1  IQ domain-containing protein E isoform X18

      Conserved Domains (3) summary
      PHA03247
      Location:185 → 502
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:90 → 171
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:61 → 257
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. XM_030254858.1 → XP_030110718.1  IQ domain-containing protein E isoform X16

      Conserved Domains (4) summary
      smart00015
      Location:314 → 334
      IQ; Calmodulin-binding motif
      PHA03307
      Location:239 → 512
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:4 → 242
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22307
      Location:201 → 343
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

    14. XM_030254856.1 → XP_030110716.1  IQ domain-containing protein E isoform X13

      Conserved Domains (2) summary
      COG1196
      Location:102 → 371
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:28 → 628
      CCDC158; Coiled-coil domain-containing protein 158

    15. XM_030254855.1 → XP_030110715.1  IQ domain-containing protein E isoform X12

      Conserved Domains (3) summary
      PLN03209
      Location:449 → 688
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00015
      Location:431 → 451
      IQ; Calmodulin-binding motif
      COG1196
      Location:147 → 433
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    16. XM_030254854.1 → XP_030110714.1  IQ domain-containing protein E isoform X11

      Conserved Domains (2) summary
      COG1196
      Location:147 → 416
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15921
      Location:73 → 673
      CCDC158; Coiled-coil domain-containing protein 158

    17. XM_030254852.1 → XP_030110712.1  IQ domain-containing protein E isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:428 → 745
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:147 → 416
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    18. XM_036165562.1 → XP_036021455.1  IQ domain-containing protein E isoform X16

      Conserved Domains (4) summary
      smart00015
      Location:314 → 334
      IQ; Calmodulin-binding motif
      PHA03307
      Location:239 → 512
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:4 → 242
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd22307
      Location:201 → 343
      Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif

    19. XM_036165560.1 → XP_036021453.1  IQ domain-containing protein E isoform X15

      Conserved Domains (3) summary
      PHA03247
      Location:236 → 553
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:141 → 222
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:112 → 308
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    20. XM_006504748.2 → XP_006504811.1  IQ domain-containing protein E isoform X17

      Conserved Domains (2) summary
      PHA03247
      Location:217 → 534
      PHA03247; large tegument protein UL36; Provisional
      TIGR02169
      Location:10 → 204
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PCQ0.1 GenPept UniProtKB/Swiss-Prot:Q6PCQ0

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