Sec63 SEC63 homolog, protein translocation regulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec63provided by MGI
Official Full Name: SEC63 homolog, protein translocation regulatorprovided by MGI
Primary source: MGI:MGI:2155302
See related: Ensembl:ENSMUSG00000019802 AllianceGenome:MGI:2155302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730478J10Rik
Summary: Predicted to enable protein transmembrane transporter activity. Acts upstream of or within liver development; nitrogen cycle metabolic process; and protein targeting to ER. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be part of Sec62/Sec63 complex. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and pancreas. Human ortholog(s) of this gene implicated in polycystic liver disease 2. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 15.6), bladder adult (RPKM 13.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B2; 10 22.89 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (42637492..42708510)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (42761496..42832514)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEC63 function regulates IRE1alpha/XBP1 activation. SEC63 and XBP1 are required for GPS cleavage and maturation of PC1, protecting against polycystic disease.
Title: Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity.
The pro-carcinogenic growth behavior of hepatocytes with low SEC63 expression in the murine model indicates a potential role for SEC63 in hepatocarcinogenesis in general.
Title: Hepatocellular carcinoma as extracolonic manifestation of Lynch syndrome indicates SEC63 as potential target gene in hepatocarcinogenesis.
Knockout of the murine Sec63 gene inhibits transport of precursor proteins into the endoplasmic reticulum.
Title: Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells.
SEC63 gene expression is up-regulated and predominantly localized in mouse decidual cells during days 5-8 of pregnancy.
Title: The uterine expression of SEC63 gene is up-regulated at implantation sites in association with the decidualization during the early pregnancy in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236341

AW319215 (e-PCR)
- UniSTS:180029

AI649014 (e-PCR)
- UniSTS:180030

G64321 (e-PCR)
- UniSTS:186612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nitrogen cycle metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info	PubMed
involved_in post-translational protein targeting to membrane, translocation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein targeting to membrane, translocation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Sec62/Sec63 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: translocation protein SEC63 homolog

Names: SEC63-like; dnaJ homolog subfamily C member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359283.1 → NP_001346212.1 translocation protein SEC63 homolog isoform 2

Status: VALIDATED

Source sequence(s)

AY024346, BC059816, BF472596, CN539237

UniProtKB/TrEMBL

Q80YG4

Conserved Domains (3) summary

smart00611
Location:209 → 714

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

pfam00226
Location:104 → 162

DnaJ; DnaJ domain

pfam14797
Location:563 → 632

SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
NM_001359284.1 → NP_001346213.1 translocation protein SEC63 homolog isoform 3

Status: VALIDATED

Source sequence(s)

AY024346, BC059816, BF472596

UniProtKB/TrEMBL

Q8K2U5

Conserved Domains (2) summary

smart00611
Location:69 → 575

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

pfam14797
Location:424 → 493

SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
NM_001359285.1 → NP_001346214.1 translocation protein SEC63 homolog isoform 4

Status: VALIDATED

Source sequence(s)

AY024346, BC059816, BF472596

UniProtKB/TrEMBL

Q8K2U5

Conserved Domains (2) summary

smart00611
Location:69 → 574

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

cl27511
Location:310 → 520

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001359286.1 → NP_001346215.1 translocation protein SEC63 homolog isoform 5

Status: VALIDATED

Source sequence(s)

AK036629, AY024346, BC059816, BF472596

Conserved Domains (2) summary

cl22482
Location:1 → 349

Sec63; Sec63 Brl domain

cl27511
Location:84 → 295

Na_Ca_ex; Sodium/calcium exchanger protein
NM_153055.3 → NP_694695.3 translocation protein SEC63 homolog isoform 1

See identical proteins and their annotated locations for NP_694695.3

Status: VALIDATED

Source sequence(s)

AY024346, BC059816, BF472596

Consensus CDS

CCDS23815.1

UniProtKB/Swiss-Prot

E9QKG1, Q8VEB9, Q8VHE0

UniProtKB/TrEMBL

Q80YG4

Related

ENSMUSP00000019937.5, ENSMUST00000019937.5

Conserved Domains (4) summary

smart00611
Location:209 → 715

SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins

pfam00226
Location:104 → 162

DnaJ; DnaJ domain

pfam05285
Location:563 → 612

SDA1; SDA1

pfam14797
Location:564 → 633

SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex