Nfam1 Nfat activating molecule with ITAM motif 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfam1provided by MGI
Official Full Name: Nfat activating molecule with ITAM motif 1provided by MGI
Primary source: MGI:MGI:1921289
See related: Ensembl:ENSMUSG00000058099 AllianceGenome:MGI:1921289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnaip; 4921501M20Rik
Summary: Predicted to enable transmembrane signaling receptor activity. Involved in B cell differentiation. Acts upstream of or within B cell receptor signaling pathway and regulation of B cell differentiation. Located in cell surface and membrane raft. Orthologous to human NFAM1 (NFAT activating protein with ITAM motif 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 12.2), mammary gland adult (RPKM 6.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.01 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82880937..82917598, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82996736..83033397, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
Title: Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.
NFAM1 modulates B cell signaling through its immunoreceptor tyrosine-based activation motif, which regulates B cell development
Title: NFAM1, an immunoreceptor tyrosine-based activation motif-bearing molecule that regulates B cell development and signaling.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within B cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of B cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NFAT activation molecule 1

Names: calcineurin/NFAT-activating ITAM-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271411.1 → NP_001258340.1 NFAT activation molecule 1 isoform a precursor

See identical proteins and their annotated locations for NP_001258340.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC133880, AK150635

Consensus CDS

CCDS70652.1

UniProtKB/Swiss-Prot

Q3UAX8, Q8R4V1, Q9D5Z3

UniProtKB/TrEMBL

Q3TBS2, Q3TD63

Related

ENSMUSP00000154945.2, ENSMUST00000231165.2
NM_001271412.1 → NP_001258341.1 NFAT activation molecule 1 isoform b

See identical proteins and their annotated locations for NP_001258341.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC133880, AK150635

UniProtKB/TrEMBL

Q3TC65, Q3TCT5
NM_001271413.1 → NP_001258342.1 NFAT activation molecule 1 isoform c

See identical proteins and their annotated locations for NP_001258342.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).

Source sequence(s)

AK048992

Consensus CDS

CCDS70651.1

UniProtKB/TrEMBL

A7E2R9

Related

ENSMUSP00000023076.6, ENSMUST00000023076.6
NM_001271414.1 → NP_001258343.1 NFAT activation molecule 1 isoform c

See identical proteins and their annotated locations for NP_001258343.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Variants 3 and 4 encode the same isoform (c).

Source sequence(s)

AC129563, AK014802, AK048992

Consensus CDS

CCDS70651.1

UniProtKB/TrEMBL

A7E2R9
NM_028728.3 → NP_083004.1 NFAT activation molecule 1 isoform d

See identical proteins and their annotated locations for NP_083004.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.

Source sequence(s)

AC129563, AK014802

Consensus CDS

CCDS27694.1

UniProtKB/TrEMBL

A7E2R9

Related

ENSMUSP00000105129.4, ENSMUST00000109503.10