Stambp STAM binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stambpprovided by MGI
Official Full Name: STAM binding proteinprovided by MGI
Primary source: MGI:MGI:1917777
See related: Ensembl:ENSMUSG00000006906 AllianceGenome:MGI:1917777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Amsh; mKIAA4198; 5330424L14Rik; 5730422L11Rik
Summary: Predicted to enable K63-linked deubiquitinase activity and protein domain specific binding activity. Acts upstream of or within negative regulation of hippocampal neuron apoptotic process and protein deubiquitination. Located in cleavage furrow. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and respiratory system. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 11.5), CNS E18 (RPKM 8.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 35.94 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (83520188..83552781, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (83543206..83575826, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that AMSH plays an important role in degrading ubiquitinated proteins and glutamate receptors in vivo
Title: AMSH is required to degrade ubiquitinated proteins in the central nervous system.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138658 (e-PCR)
- UniSTS:220745

RH124387 (e-PCR)
- UniSTS:161209

AW107289 (e-PCR)
- UniSTS:179406

PMC100023P1 (e-PCR)
- UniSTS:270053

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables K63-linked deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked deubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein deubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein deubiquitination	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: STAM-binding protein

Names: associated molecule with the SH3 domain of STAM

NP_001349007.1

EC 3.1.2.15

NP_001349008.1

EC 3.1.2.15

NP_001349009.1

EC 3.1.2.15

NP_077201.1

EC 3.1.2.15

XP_006506646.1

EC 3.1.2.15

XP_006506647.1

EC 3.1.2.15

XP_030111450.1

EC 3.1.2.15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362078.1 → NP_001349007.1 STAM-binding protein

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.

Source sequence(s)

AB010123, AK136961, CJ073582

Consensus CDS

CCDS20280.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Related

ENSMUSP00000146294.2, ENSMUST00000206592.2

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain
NM_001362079.1 → NP_001349008.1 STAM-binding protein

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AB010123, AK019907, CJ073582

Consensus CDS

CCDS20280.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain
NM_001362080.1 → NP_001349009.1 STAM-binding protein

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AC090649

Consensus CDS

CCDS20280.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Related

ENSMUSP00000145871.2, ENSMUST00000206400.2

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain
NM_024239.2 → NP_077201.1 STAM-binding protein

See identical proteins and their annotated locations for NP_077201.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.

Source sequence(s)

AB010123, AK139391, CJ074803

Consensus CDS

CCDS20280.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Related

ENSMUSP00000070876.8, ENSMUST00000068054.9

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

83520188..83552781 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030255590.2 → XP_030111450.1 STAM-binding protein isoform X1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain
XM_006506584.4 → XP_006506647.1 STAM-binding protein isoform X1

See identical proteins and their annotated locations for XP_006506647.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain
XM_006506583.4 → XP_006506646.1 STAM-binding protein isoform X1

See identical proteins and their annotated locations for XP_006506646.1

UniProtKB/Swiss-Prot

Q3UTI9, Q9CQ26

UniProtKB/TrEMBL

Q3TGB1

Conserved Domains (2) summary

cd08066
Location:254 → 424

MPN_AMSH_like; Mov34/MPN/PAD-1 family

pfam08969
Location:8 → 114

USP8_dimer; USP8 dimerization domain