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    Inf2 inverted formin, FH2 and WH2 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 70435, updated on 9-Dec-2024

    Summary

    Official Symbol
    Inf2provided by MGI
    Official Full Name
    inverted formin, FH2 and WH2 domain containingprovided by MGI
    Primary source
    MGI:MGI:1917685
    See related
    Ensembl:ENSMUSG00000037679 AllianceGenome:MGI:1917685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG629699; 2610204M08Rik
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Acts upstream of or within actin nucleation; gene expression; and regulation of cellular component size. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 15.2), frontal lobe adult (RPKM 13.7) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Inf2 in Genome Data Viewer
    Location:
    12 F1; 12 61.2 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112555121..112581991)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112588744..112615557)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 179 Neighboring gene STARR-seq mESC enhancer starr_33351 Neighboring gene predicted gene, 53770 Neighboring gene predicted gene, 40584 Neighboring gene STARR-positive B cell enhancer ABC_E5358 Neighboring gene STARR-seq mESC enhancer starr_33358 Neighboring gene predicted gene, 30048 Neighboring gene STARR-positive B cell enhancer ABC_E7189 Neighboring gene STARR-positive B cell enhancer ABC_E5359 Neighboring gene STARR-positive B cell enhancer ABC_E5360 Neighboring gene STARR-positive B cell enhancer ABC_E3068 Neighboring gene adenylosuccinate synthase 1 Neighboring gene STARR-positive B cell enhancer ABC_E601 Neighboring gene predicted gene, 30101

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107363, MGC143801, MGC143802

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inverted formin-2
    Names
    formin, inverted

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374199.1NP_001361128.1  inverted formin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124373
      UniProtKB/Swiss-Prot
      Q0GNC1, Q14C56, Q499F7, Q6P9T3
      Conserved Domains (5) summary
      smart00246
      Location:10051020
      WH2; Wiskott Aldrich syndrome homology region 2
      PHA03307
      Location:10341262
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587951
      FH2; Formin Homology 2 Domain
    2. NM_198411.3NP_940803.2  inverted formin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124373
      Consensus CDS
      CCDS36571.1
      UniProtKB/Swiss-Prot
      Q0GNC1, Q14C56, Q499F7, Q6P9T3
      UniProtKB/TrEMBL
      E9QLA5
      Related
      ENSMUSP00000098591.3, ENSMUST00000101029.4
      Conserved Domains (5) summary
      smart00246
      Location:10051020
      WH2; Wiskott Aldrich syndrome homology region 2
      PHA03307
      Location:10341259
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587951
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112555121..112581991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246906.2XP_030102766.1  inverted formin-2 isoform X2

      UniProtKB/Swiss-Prot
      Q0GNC1, Q14C56, Q499F7, Q6P9T3
      Conserved Domains (5) summary
      smart00246
      Location:10051020
      WH2; Wiskott Aldrich syndrome homology region 2
      PHA03307
      Location:10341278
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587951
      FH2; Formin Homology 2 Domain
    2. XM_030246905.2XP_030102765.1  inverted formin-2 isoform X1

      UniProtKB/Swiss-Prot
      Q0GNC1, Q14C56, Q499F7, Q6P9T3
      Conserved Domains (5) summary
      smart00246
      Location:10051020
      WH2; Wiskott Aldrich syndrome homology region 2
      PHA03307
      Location:10341278
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587951
      FH2; Formin Homology 2 Domain
    3. XM_030246907.2XP_030102767.1  inverted formin-2 isoform X3

      UniProtKB/Swiss-Prot
      Q0GNC1, Q14C56, Q499F7, Q6P9T3
      Conserved Domains (5) summary
      smart00246
      Location:10051020
      WH2; Wiskott Aldrich syndrome homology region 2
      PHA03307
      Location:10261251
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587951
      FH2; Formin Homology 2 Domain
    4. XM_030246909.2XP_030102769.1  inverted formin-2 isoform X4

      Conserved Domains (3) summary
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587743
      FH2; Formin Homology 2 Domain
    5. XM_030246910.2XP_030102770.1  inverted formin-2 isoform X5

      Conserved Domains (3) summary
      pfam06367
      Location:156341
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:14152
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:587743
      FH2; Formin Homology 2 Domain
    6. XM_036157610.1XP_036013503.1  inverted formin-2 isoform X6

      Conserved Domains (3) summary
      PHA03307
      Location:346574
      PHA03307; transcriptional regulator ICP4; Provisional
      cd22061
      Location:309338
      WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
      cl19758
      Location:1263
      FH2; Formin Homology 2 Domain

    RNA

    1. XR_003950077.2 RNA Sequence

    2. XR_003950078.2 RNA Sequence

    3. XR_004937541.1 RNA Sequence