Mtcl2 microtubule crosslinking factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtcl2provided by MGI
Official Full Name: microtubule crosslinking factor 2provided by MGI
Primary source: MGI:MGI:2444575
See related: Ensembl:ENSMUSG00000055485 AllianceGenome:MGI:2444575
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Soga; Soga1; 9830001H06Rik; D430036N24Rik
Summary: Involved in insulin receptor signaling pathway; negative regulation of gluconeogenesis; and regulation of autophagy. Located in extracellular space and microtubule. Orthologous to human MTCL2 (microtubule crosslinking factor 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 16.8), lung adult (RPKM 13.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.91 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156852361..156921185, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (157010441..157079667, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The novel protein SOGA1 was confirmed to colocalize with a microtubule-associated protein CLASP2 and with tubulin, which identifies SOGA1 as a new microtubule-associated protein.
Title: Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: microtubule cross-linking factor 2

Names: SOGA family member 1; protein SOGA1; suppressor of glucose by autophagy; suppressor of glucose, autophagy associated 1; suppressor of glucose, autophagy-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164663.1 → NP_001158135.1 microtubule cross-linking factor 2

Status: VALIDATED

Source sequence(s)

AK147227, AL669932, CJ164427

Consensus CDS

CCDS50781.1

UniProtKB/Swiss-Prot

A2ACV6, E1U8D0

Related

ENSMUSP00000066556.7, ENSMUST00000069098.7

Conserved Domains (3) summary

pfam00261
Location:294 → 555

Tropomyosin; Tropomyosin

pfam11365
Location:378 → 472

DUF3166; Protein of unknown function (DUF3166)

pfam14818
Location:1065 → 1202

DUF4482; Domain of unknown function (DUF4482)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

156852361..156921185 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319023.3 → XP_017174512.3 microtubule cross-linking factor 2 isoform X2

Conserved Domains (5) summary

PHA03307
Location:28 → 211

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:214 → 548

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:251 → 1090

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam11365
Location:504 → 593

SOGA; Protein SOGA

pfam14818
Location:1018 → 1156

DUF4482; Domain of unknown function (DUF4482)
XM_036162310.1 → XP_036018203.1 microtubule cross-linking factor 2 isoform X1

Conserved Domains (5) summary

PHA03307
Location:28 → 211

PHA03307; transcriptional regulator ICP4; Provisional

COG1196
Location:214 → 548

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:251 → 1108

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam11365
Location:504 → 593

SOGA; Protein SOGA

pfam14818
Location:1065 → 1201

DUF4482; Domain of unknown function (DUF4482)