Nup85 nucleoporin 85 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nup85provided by MGI
Official Full Name: nucleoporin 85provided by MGI
Primary source: MGI:MGI:3046173
See related: Ensembl:ENSMUSG00000020739 AllianceGenome:MGI:3046173
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcnt1; frount
Summary: Predicted to enable CCR2 chemokine receptor binding activity. Predicted to be a structural constituent of nuclear pore. Acts upstream of or within lamellipodium assembly and macrophage chemotaxis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of nuclear pore outer ring. Predicted to colocalize with kinetochore. Is expressed in several structures, including blastocyst; cerebral cortex ventricular layer; early embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14.5 (RPKM 39.0), CNS E11.5 (RPKM 38.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.87 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (115455264..115474750)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115564432..115583924)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
Title: NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease.
Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
Title: Deficient chaperone-mediated autophagy in macrophage aggravates inflammation of nonalcoholic steatohepatitis by targeting Nup85.
the chemokine signal regulator FROUNT is identified as a target to control tumor-associated macrophages.
Title: Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties.
FROUNT links activated CCR2 to the PI(3)K-Rac-lamellipodium protrusion cascade in monocyte chemotaxis
Title: Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

42.MHAa95d6.seq (e-PCR)
- UniSTS:124449

Cda0wb11 (e-PCR)
- UniSTS:28791

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR2 chemokine receptor binding	ISA Inferred from Sequence Alignment more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in nephron development	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISA Inferred from Sequence Alignment more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
colocalizes_with kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore outer ring	ISO Inferred from Sequence Orthology more info
part_of nuclear pore outer ring	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISA Inferred from Sequence Alignment more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear pore complex protein Nup85

Names: 85 kDa nucleoporin; nucleoporin Nup85; pericentrin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002929.4 → NP_001002929.3 nuclear pore complex protein Nup85

See identical proteins and their annotated locations for NP_001002929.3

Status: VALIDATED

Source sequence(s)

BC079856, BY032258, CF738553

Consensus CDS

CCDS25640.1

UniProtKB/Swiss-Prot

A2A9W9, A2A9X0, Q8R480, Q9CYI9

Related

ENSMUSP00000021085.5, ENSMUST00000021085.11

Conserved Domains (1) summary

pfam07575
Location:53 → 606

Nucleopor_Nup85; Nup85 Nucleoporin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

115455264..115474750

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533670.5 → XP_006533733.1 nuclear pore complex protein Nup85 isoform X1

Conserved Domains (1) summary

pfam07575
Location:53 → 598

Nucleopor_Nup85; Nup85 Nucleoporin
XM_006533671.4 → XP_006533734.1 nuclear pore complex protein Nup85 isoform X2

Conserved Domains (1) summary

pfam07575
Location:31 → 584

Nucleopor_Nup85; Nup85 Nucleoporin
XM_030246116.2 → XP_030101976.1 nuclear pore complex protein Nup85 isoform X3

Conserved Domains (1) summary

pfam07575
Location:31 → 576

Nucleopor_Nup85; Nup85 Nucleoporin