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    Med10 mediator complex subunit 10 [ Mus musculus (house mouse) ]

    Gene ID: 28077, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Med10provided by MGI
    Official Full Name
    mediator complex subunit 10provided by MGI
    Primary source
    MGI:MGI:106331
    See related
    Ensembl:ENSMUSG00000021598 AllianceGenome:MGI:106331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D13Wsu50e
    Summary
    Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and somatic stem cell population maintenance. Part of mediator complex. Is expressed in embryo; extraembryonic component; and tibialis anterior. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.5), ovary adult (RPKM 9.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med10 in Genome Data Viewer
    Location:
    13 C1; 13 35.55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (69950467..69964221)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (69802348..69816102)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930547H16 gene Neighboring gene small EDRK-rich factor 2 pseudogene Neighboring gene RIKEN cDNA 4933416O17 gene Neighboring gene STARR-seq mESC enhancer starr_34946 Neighboring gene predicted gene, 36019

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Kolonay DW, et al. Front Cell Dev Biol, 2024. PMID 38690566, Free PMC Article
    2. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
    3. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. Mittler G, et al. EMBO Rep, 2001 Sep. PMID 11559591, Free PMC Article
    4. Mediator and cohesin connect gene expression and chromatin architecture. Kagey MH, et al. Nature, 2010 Sep 23. PMID 20720539, Free PMC Article
    5. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 10
    Names
    mediator of RNA polymerase II transcription, subunit 10 homolog (NUT2, S. cerevisiae)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378925.1 → NP_001365854.1  mediator of RNA polymerase II transcription subunit 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC122371
      Conserved Domains (1) summary
      pfam09748
      Location:38 → 155
      Med10; Transcription factor subunit Med10 of Mediator complex

    2. NM_138596.2 → NP_613062.1  mediator of RNA polymerase II transcription subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_613062.1

      Status: PROVISIONAL

      Source sequence(s)
      AK013992
      Consensus CDS
      CCDS26625.1
      UniProtKB/Swiss-Prot
      Q3U0W8, Q80VV0, Q9CXU0
      Related
      ENSMUSP00000022089.9, ENSMUST00000022089.10
      Conserved Domains (1) summary
      pfam09748
      Location:9 → 126
      Med10; Transcription factor subunit Med10 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      69950467..69964221
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517275.3 → XP_006517338.1  mediator of RNA polymerase II transcription subunit 10 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VMY2
      Related
      ENSMUSP00000152144.2, ENSMUST00000221893.2
      Conserved Domains (1) summary
      pfam09748
      Location:40 → 132
      Med10; Transcription factor subunit Med10 of Mediator complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CXU0.1 GenPept UniProtKB/Swiss-Prot:Q9CXU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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