Pgrmc2 progesterone receptor membrane component 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pgrmc2provided by MGI
Official Full Name: progesterone receptor membrane component 2provided by MGI
Primary source: MGI:MGI:1918054
See related: Ensembl:ENSMUSG00000049940 AllianceGenome:MGI:1918054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DG6; PMBP; 4631434O19Rik; 5730409G06Rik
Summary: Enables heme binding activity and heme transmembrane transporter activity. Involved in heme transport. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; neural retina; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human PGRMC2 (progesterone receptor membrane component 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 16.9), ovary adult (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 19.66 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (41020772..41037443, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (41066326..41083046, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gain-of-function of progesterone receptor membrane component 2 ameliorates ischemic brain injury.
Title: Gain-of-function of progesterone receptor membrane component 2 ameliorates ischemic brain injury.
Ensuing alterations in gene expression caused severe mitochondrial defects that rendered adipose-specific PGRMC2-null mice unable to activate adaptive thermogenesis and prone to greater metabolic deterioration when fed a high-fat diet
Title: PGRMC2 is an intracellular haem chaperone critical for adipocyte function.
survival of adult primordial ovarian follicles dependent in part on progesterone receptor membrane component 1 and 2
Title: PGRMC1/2 promotes luteal vascularization and maintains the primordial follicles of mice.
required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan.
Title: Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit326 (e-PCR), detects polymorphism
- UniSTS:142392

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables heme transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heme transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: membrane-associated progesterone receptor component 2

Names: progesterone membrane binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027558.2 → NP_081834.1 membrane-associated progesterone receptor component 2

See identical proteins and their annotated locations for NP_081834.1

Status: VALIDATED

Source sequence(s)

AC100511

Consensus CDS

CCDS50899.1

UniProtKB/Swiss-Prot

Q80UU9

Related

ENSMUSP00000056643.8, ENSMUST00000058578.8

Conserved Domains (1) summary

pfam00173
Location:96 → 194

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain