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    Smtnl2 smoothelin-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 276829, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smtnl2provided by MGI
    Official Full Name
    smoothelin-like 2provided by MGI
    Primary source
    MGI:MGI:2442764
    See related
    Ensembl:ENSMUSG00000045667 AllianceGenome:MGI:2442764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D130058I21Rik
    Summary
    Predicted to be involved in actin cytoskeleton organization. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Is expressed in several structures, including adipose tissue; femur; heart; lung; and metanephros. Orthologous to human SMTNL2 (smoothelin like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 9.3), mammary gland adult (RPKM 6.8) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Smtnl2 in Genome Data Viewer
    Location:
    11 B4; 11 44.15 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72279989..72302539, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72389163..72411713, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tektin 1 Neighboring gene predicted gene, 34317 Neighboring gene microRNA 6338 Neighboring gene STARR-seq mESC enhancer starr_29906 Neighboring gene STARR-positive B cell enhancer ABC_E10683 Neighboring gene STARR-positive B cell enhancer ABC_E8422 Neighboring gene gamma-glutamyltransferase 6 Neighboring gene MYB binding protein (P160) 1a Neighboring gene SPNS lysolipid transporter 2, sphingosine-1-phosphate

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177776.3NP_808444.1  smoothelin-like protein 2

      See identical proteins and their annotated locations for NP_808444.1

      Status: PROVISIONAL

      Source sequence(s)
      AL662812
      Consensus CDS
      CCDS24985.1
      UniProtKB/Swiss-Prot
      Q8CI12
      UniProtKB/TrEMBL
      Q5F247
      Related
      ENSMUSP00000059043.7, ENSMUST00000050226.7
      Conserved Domains (2) summary
      cd00014
      Location:349453
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cl01090
      Location:5689
      SlyX; SlyX

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72279989..72302539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156740.1XP_036012633.1  smoothelin-like protein 2 isoform X1

      Conserved Domains (1) summary
      cd21261
      Location:244350
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
    2. XM_036156742.1XP_036012635.1  smoothelin-like protein 2 isoform X4

      Conserved Domains (1) summary
      cd21261
      Location:226332
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
    3. XM_006533470.3XP_006533533.1  smoothelin-like protein 2 isoform X5

      Conserved Domains (1) summary
      pfam00307
      Location:220325
      CH; Calponin homology (CH) domain
    4. XM_036156743.1XP_036012636.1  smoothelin-like protein 2 isoform X6

      Conserved Domains (1) summary
      cd21261
      Location:160266
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
    5. XM_036156741.1XP_036012634.1  smoothelin-like protein 2 isoform X3

      Conserved Domains (1) summary
      cd21261
      Location:230336
      CH_SMTNL2; calponin homology (CH) domain found in smoothelin-like protein 2
    6. XM_006533469.4XP_006533532.1  smoothelin-like protein 2 isoform X2

      Conserved Domains (1) summary
      pfam00307
      Location:243348
      CH; Calponin homology (CH) domain