stx2A Shiga toxin 2 subunit A [Escherichia coli O157:H7 str. Sakai] - Gene

Summary

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Gene symbol: stx2A
Gene description: Shiga toxin 2 subunit A
Locus tag: ECs_1205
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli O157:H7 str. Sakai (strain: Sakai, substrain: RIMD 0509952, serovar: O157:H7)
Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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Genomic context

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Sequence:: NC_002695.2 (1267107..1268066)

NC_002695.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_002695.2

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction.
Title: Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction.
Genome Sequence Analysis and Characterization of Shiga Toxin 2 Production by Escherichia coli O157:H7 Strains Associated With a Laboratory Infection.
Title: Genome Sequence Analysis and Characterization of Shiga Toxin 2 Production by Escherichia coli O157:H7 Strains Associated With a Laboratory Infection.
Pathogenic potential assessment of the Shiga toxin-producing Escherichia coli by a source attribution-considered machine learning model.
Title: Pathogenic potential assessment of the Shiga toxin-producing Escherichia coli by a source attribution-considered machine learning model.
A single proteolytic cleavage in the Stx2a A-subunit, resulting into two fragments (A1 and A2) linked by a disulfide bridge (cleaved Stx2a), dictates different binding abilities.
Title: The structure of the Shiga toxin 2a A-subunit dictates the interactions of the toxin with blood components.
Shiga toxin 2 subunit A (Stx) translocation across the T84 colon carcinoma cells monolayer is lower in less virulent seropathotype (SPT) group of Stx-producing Escherichia coli strains (STEC) . Stx penetration occurs via a transcellular pathway independently from bacterial type III secretion and attaching and effacing lesion formation. Stx transcytosis across the gut epithelium indicates STEC pathogenicity for humans.
Title: Shiga toxin 2 translocation across intestinal epithelium is linked to virulence of Shiga toxin-producing Escherichia coli in humans.
The presence of stx2 in stool could be used as risk predictor at an early stage. Shiga toxin-producing Escherichia coli isolates with stx2 toxin and intimin protein were significantly associated with bloody diarrhea.
Title: Shiga Toxin-Producing Escherichia coli Infection in Jönköping County, Sweden: Occurrence and Molecular Characteristics in Correlation With Clinical Symptoms and Duration of stx Shedding.

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General protein information

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Preferred Names: Shiga toxin 2 subunit A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_002695.2 Reference assembly

Range

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_309232.1 Shiga toxin 2 subunit A [Escherichia coli O157:H7 str. Sakai]

See identical proteins and their annotated locations for NP_309232.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A0D5CVE8, H9TVI5, Q5WPW7, Q8KU16

Conserved Domains (1) summary

pfam00161
Location:30 → 231

RIP; Ribosome inactivating protein