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    mngB alpha-mannosidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945359, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mngB
    Official Full Name
    alpha-mannosidase
    Primary source
    ECOCYC:EG13236
    Locus tag
    b0732
    See related
    ASAP:ABE-0002495
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0720; ybgG
    Summary
    AFMB Structural Genomics target Number 109 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13236]. The mngB gene encodes an alpha-mannosidase responsible for the conversion of 2-O-(6-phospho--mannosyl)-D-glycerate to mannose-6-phosphate and glycerate in the 2-O--Mannosyl-D-glycerate (MG) degradation pathway. [More information is available at EcoCyc: EG13236].
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    Genomic context

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    Sequence:
    NC_000913.3 (767978..770611)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor MngR Neighboring gene 2-O-alpha-mannosyl-D-glycerate specific PTS enzyme II Neighboring gene cytochrome bd-I subunit 1 Neighboring gene cytochrome bd-I subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the heat-responsive genes in Escherichia coli. Utsumi R, et al. Biosci Biotechnol Biochem, 1996 Feb. PMID 9063979
    2. Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor. Sampaio MM, et al. J Biol Chem, 2004 Feb 13. PMID 14645248
    3. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    4. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503
    5. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Riley M, et al. Nucleic Acids Res, 2006. PMID 16397293, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-mannosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      767978..770611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415260.1 alpha-mannosidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415260.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6M9WXW4
      Conserved Domains (1) summary
      PRK09819
      Location:2 → 875
      PRK09819; mannosylglycerate hydrolase
    Nucleotide Protein
    Heading Accession and Version

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