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    evgS sensor histidine kinase EvgS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946844, updated on 3-Dec-2024

    Summary

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    Official Symbol
    evgS
    Official Full Name
    sensor histidine kinase EvgS
    Primary source
    ECOCYC:EG11610
    Locus tag
    b2370
    See related
    ASAP:ABE-0007819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2366
    Summary
    Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG11610]. Sensor kinase-phosphotransferase EvgS is a member of the two-component regulatory system EvgS/EvgA. [More information is available at EcoCyc: EG11610].
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    Genomic context

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    Sequence:
    NC_000913.3 (2484374..2487967)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tripartite efflux pump membrane subunit EmrY Neighboring gene tripartite efflux pump membrane fusion protein EmrK Neighboring gene protein EvgL Neighboring gene DNA-binding transcriptional activator EvgA Neighboring gene acetyl-CoA:oxalate CoA-transferase Neighboring gene putative transport protein YfdV

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli. Eguchi Y, et al. J Bacteriol, 2014 Sep. PMID 24957621, Free PMC Article
    2. Molecular interaction between proteins involved in EvgAS signal transduction of Escherichia coli. Tanabe H, et al. Biosci Biotechnol Biochem, 1998 Jan. PMID 9501520
    3. Identification of the promoter region and the transcriptional regulatory sequence of the evgAS operon of Escherichia coli. Tanabe H, et al. Biosci Biotechnol Biochem, 1998 Feb. PMID 9532784
    4. Cloning and sequence analysis of the evgAS genes involved in signal transduction of Escherichia coli K-12. Utsumi R, et al. Nucleic Acids Symp Ser, 1992. PMID 1289796
    5. Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins. Perraud AL, et al. Mol Microbiol, 1998 Mar. PMID 9535079

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors show that histidine 226 is required for induction and that it is structurally colocated with a proline residue (P522) at the top of the predicted transmembrane helix that is expected to play a key role in passing information to the cytoplasmic domains.
      Title: Structural and Functional Analysis of the Escherichia coli Acid-Sensing Histidine Kinase EvgS.
    2. Data indicate that replacement of Asp in the receiver domain of hybrid sensory histidine kinase EvgS by Ala markedly promoted phosphorylation at His in the histidine kinase (HK) domain.
      Title: Functional Characterization of the Receiver Domain for Phosphorelay Control in Hybrid Sensor Kinases.
    3. PAS domain of the EvgS sensor kinase is responsible for acid resistance.
      Title: Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to acidic pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to metal ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sensor histidine kinase EvgS
    NP_416871.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2484374..2487967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416871.1 sensor histidine kinase EvgS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416871.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7JPH4
      Conserved Domains (1) summary
      PRK09959
      Location:1 → 1197
      PRK09959; acid-sensing system histidine kinase EvgS
    Nucleotide Protein
    Heading Accession and Version

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