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    gadY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 2847729, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gadY
    Primary source
    ECOCYC:G0-8914
    Locus tag
    b4452
    See related
    ASAP:ABE-0047272
    Gene type
    ncRNA
    RNA name
    other
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3500; IS183
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    Genomic context

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    Sequence:
    NC_000913.3 (3664864..3664969)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump RND permease MdtF Neighboring gene DNA-binding transcriptional dual regulator GadW Neighboring gene DNA-binding transcriptional dual regulator GadX Neighboring gene glutamate decarboxylase A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constitutive expression of the sRNA GadY decreases acetate production and improves E. coli growth. Negrete A, et al. Microb Cell Fact, 2015 Sep 18. PMID 26383169, Free PMC Article
    2. Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA. Zhang S, et al. Front Cell Infect Microbiol, 2024. PMID 39108982, Free PMC Article
    3. Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli. Yu Z, et al. J Bacteriol, 2011 Mar. PMID 21216990, Free PMC Article
    4. RNase III participates in GadY-dependent cleavage of the gadX-gadW mRNA. Opdyke JA, et al. J Mol Biol, 2011 Feb 11. PMID 21147125, Free PMC Article
    5. GadY, a small-RNA regulator of acid response genes in Escherichia coli. Opdyke JA, et al. J Bacteriol, 2004 Oct. PMID 15466020, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA.
      Title: Small RNA GadY in Escherichia coli enhances conjugation system of IncP-1 by targeting SdiA.
    2. The constitutive expression of GadY improves E. coli growth at pH 6.0 by deactivating the expression of the GDS in the late exponential growth phase.
      Title: Constitutive expression of the sRNA GadY decreases acetate production and improves E. coli growth.
    3. The authors found that the overexpression of the GadX and GadY regulators of the glutamate-dependent acid resistance system complemented the growth defect of YidC-depleted cells.
      Title: Activators of the glutamate-dependent acid resistance system alleviate deleterious effects of YidC depletion in Escherichia coli.
    4. Base pairing of the GadY small RNA with the intergenic region of the gadX-gadW mRNA results in directed processing events within the region of complementarity. multiple enzymes are involved in the GadYdirected cleavage including RNase III.
      Title: RNase III participates in GadY-dependent cleavage of the gadX-gadW mRNA.
    5. GadX/GadW-dependent activation of the acid fitness island is controlled at the gadX-gadW intergenic region, in which the gadY gene is located and transcribed divergently from gadW.
      Title: GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites.
    Submit: New GeneRIF Correction

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