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    Csl citrate synthase like [ Mus musculus (house mouse) ]

    Gene ID: 71832, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cslprovided by MGI
    Official Full Name
    citrate synthase likeprovided by MGI
    Primary source
    MGI:MGI:1919082
    See related
    Ensembl:ENSMUSG00000046934 AllianceGenome:MGI:1919082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700007H16Rik
    Summary
    Predicted to enable citrate (Si)-synthase activity. Predicted to be involved in several processes, including acetyl-CoA metabolic process; carboxylic acid metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Csl in Genome Data Viewer
    Location:
    10 D1; 10 51.2 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (99593567..99595346, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (99757705..99759658, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 20110 Neighboring gene mediator of cell motility 1 pseudogene Neighboring gene predicted gene, 35101 Neighboring gene STARR-seq mESC enhancer starr_27728 Neighboring gene predicted gene, 35206 Neighboring gene STARR-seq mESC enhancer starr_27729 Neighboring gene predicted gene, 35437

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extra-mitochondrial citrate synthase controls cAMP-dependent pathway during sperm acrosome reaction in mice. Kang W, et al. MicroPubl Biol, 2022. PMID 35663411, Free PMC Article
    2. Neuronal expression of Ca(2+) oscillation initiator is linked to rapid neonatal growth in mice. Kang W, et al. MicroPubl Biol, 2020 Nov 12. PMID 33274323, Free PMC Article
    3. Overdue Calcium Oscillation Causes Polyspermy but Possibly Permits Normal Development in Mouse Eggs. Fukuoka M, et al. Int J Mol Sci, 2023 Dec 24. PMID 38203456, Free PMC Article
    4. Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation. Hirose N, et al. Life (Basel), 2023 Apr 10. PMID 37109509, Free PMC Article
    5. Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. Kang W, et al. Lab Invest, 2020 Apr. PMID 31857692, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables citrate (Si)-synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate (Si)-synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in citrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxaloacetate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    citrate synthase-like protein
    NP_082221.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027945.4 → NP_082221.2  citrate synthase-like protein

      See identical proteins and their annotated locations for NP_082221.2

      Status: VALIDATED

      Source sequence(s)
      AC158633
      Consensus CDS
      CCDS24149.1
      UniProtKB/TrEMBL
      Q80X68, Q9DAM4
      Related
      ENSMUSP00000052373.5, ENSMUST00000056085.6
      Conserved Domains (2) summary
      cd06105
      Location:33 → 459
      ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
      PLN02456
      Location:29 → 459
      PLN02456; citrate synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      99593567..99595346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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