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    Ddx60 DExD/H box helicase 60 [ Mus musculus (house mouse) ]

    Gene ID: 234311, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddx60provided by MGI
    Official Full Name
    DExD/H box helicase 60provided by MGI
    Primary source
    MGI:MGI:2384570
    See related
    Ensembl:ENSMUSG00000037921 AllianceGenome:MGI:2384570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830118M07
    Summary
    Enables RNA binding activity. Acts upstream of or within defense response to virus. Located in cytoplasm. Is expressed in lens. Orthologous to human DDX60 (DExD/H-box helicase 60). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    See Ddx60 in Genome Data Viewer
    Location:
    8 B3.1; 8 31.51 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (62381155..62491278)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61928073..62037704)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene RIKEN cDNA 4930512H18 gene Neighboring gene lysyl-tRNA synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21603 Neighboring gene STARR-seq mESC enhancer starr_21604 Neighboring gene annexin A10 Neighboring gene STARR-seq mESC enhancer starr_21605 Neighboring gene predicted gene 2961

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC19297

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MDA-5 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX60
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
    NP_001280712.1
    XP_006509456.1
    XP_006509459.1
    XP_011240516.1
    XP_017168186.1
    XP_017168187.1
    XP_036009806.1
    XP_036009807.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293783.2NP_001280712.1  probable ATP-dependent RNA helicase DDX60

      See identical proteins and their annotated locations for NP_001280712.1

      Status: VALIDATED

      Source sequence(s)
      AC139846, AC144858
      Consensus CDS
      CCDS52556.2
      UniProtKB/TrEMBL
      E9PZQ1, G3X9F7
      Related
      ENSMUSP00000070741.8, ENSMUST00000070631.15
      Conserved Domains (3) summary
      smart00490
      Location:12521328
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:760951
      DEXDc; DEAD-like helicases superfamily
      pfam00270
      Location:766920
      DEAD; DEAD/DEAH box helicase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      62381155..62491278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509393.3XP_006509456.1  probable ATP-dependent RNA helicase DDX60 isoform X1

      UniProtKB/TrEMBL
      E9PZQ1
      Conserved Domains (2) summary
      COG4581
      Location:6081318
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      cd18025
      Location:713885
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
    2. XM_017312697.3XP_017168186.1  probable ATP-dependent RNA helicase DDX60 isoform X5

      Conserved Domains (1) summary
      cd18025
      Location:761938
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
    3. XM_006509396.3XP_006509459.1  probable ATP-dependent RNA helicase DDX60 isoform X6

      Conserved Domains (1) summary
      cd18025
      Location:761938
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
    4. XM_011242214.3XP_011240516.1  probable ATP-dependent RNA helicase DDX60 isoform X3

      Conserved Domains (1) summary
      cd18025
      Location:761938
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
    5. XM_036153914.1XP_036009807.1  probable ATP-dependent RNA helicase DDX60 isoform X4

      Conserved Domains (1) summary
      cd18025
      Location:761938
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60
    6. XM_017312698.3XP_017168187.1  probable ATP-dependent RNA helicase DDX60 isoform X7

      Conserved Domains (1) summary
      cl28899
      Location:761858
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    7. XM_036153913.1XP_036009806.1  probable ATP-dependent RNA helicase DDX60 isoform X2

      Conserved Domains (2) summary
      COG4581
      Location:356967
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      cd18025
      Location:357534
      DEXHc_DDX60; DEXH-box helicase domain of DEAD box protein 60

    RNA

    1. XR_001778429.3 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001081215.1: Suppressed sequence

      Description
      NM_001081215.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    2. NM_144928.1: Suppressed sequence

      Description
      NM_144928.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.