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    Nek1 NIMA (never in mitosis gene a)-related expressed kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 18004, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nek1provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 1provided by MGI
    Primary source
    MGI:MGI:97303
    See related
    Ensembl:ENSMUSG00000031644 AllianceGenome:MGI:97303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    kat; D8Ertd790e
    Summary
    Enables 14-3-3 protein binding activity. Involved in regulation of DNA damage checkpoint. Acts upstream of or within several processes, including DNA damage response; response to ionizing radiation; and spermatogenesis. Located in centrosome and nucleus. Is expressed in several structures, including ganglia; gut; hemolymphoid system gland; metanephros; and reproductive system. Used to study autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 24; asphyxiating thoracic dystrophy; orofaciodigital syndrome II; and short-rib thoracic dysplasia 6 with or without polydactyly. Orthologous to human NEK1 (NIMA related kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.0), frontal lobe adult (RPKM 6.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nek1 in Genome Data Viewer
    Location:
    8 B3.1; 8 30.91 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61446184..61584383)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (60993157..61131349)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:63369016-63369317 Neighboring gene histone PARylation factor 1 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene STARR-seq mESC enhancer starr_21578 Neighboring gene predicted gene, 18394 Neighboring gene STARR-positive B cell enhancer ABC_E10500 Neighboring gene STARR-positive B cell enhancer ABC_E6639 Neighboring gene STARR-positive B cell enhancer ABC_E11383 Neighboring gene STARR-seq mESC enhancer starr_21581 Neighboring gene SH3 domain containing ring finger 1 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene predicted gene, 40499

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Spontaneous (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC189817

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in pericentriolar material ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek1
    Names
    NIMA-related kinase 1
    NY-REN-55 antigen
    Nek1 serine/threonine- and tyrosine-specific protein kinase
    kidney, anemia and testis
    never in mitosis A-related kinase 1
    nimA-related protein kinase 1
    NP_001280566.1
    NP_001280567.1
    NP_001280568.1
    NP_001401155.1
    NP_001401156.1
    NP_001401157.1
    NP_001401158.1
    NP_001401159.1
    NP_780298.2
    XP_030099200.1
    XP_036009687.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293637.1NP_001280566.1  serine/threonine-protein kinase Nek1 isoform 1

      See identical proteins and their annotated locations for NP_001280566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC159302, AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS85541.1
      UniProtKB/TrEMBL
      B2RXX0, Q69Z74
      Related
      ENSMUSP00000147809.2, ENSMUST00000211672.2
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    2. NM_001293638.1NP_001280567.1  serine/threonine-protein kinase Nek1 isoform 2

      See identical proteins and their annotated locations for NP_001280567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC159302, AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS80879.1
      UniProtKB/TrEMBL
      B7ZWK0, Q69Z74
      Related
      ENSMUSP00000113932.2, ENSMUST00000120689.8
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    3. NM_001293639.1NP_001280568.1  serine/threonine-protein kinase Nek1 isoform 4

      See identical proteins and their annotated locations for NP_001280568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded protein (isoform 4) is shorter, compared to isoform 1.
      Source sequence(s)
      AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS85542.1
      UniProtKB/TrEMBL
      B2RXQ4, Q69Z74
      Related
      ENSMUSP00000147258.2, ENSMUST00000211256.2
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    4. NM_001414226.1NP_001401155.1  serine/threonine-protein kinase Nek1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134339, AC159302
      UniProtKB/TrEMBL
      Q69Z74
    5. NM_001414227.1NP_001401156.1  serine/threonine-protein kinase Nek1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC134339, AC159302
      UniProtKB/TrEMBL
      Q69Z74
    6. NM_001414228.1NP_001401157.1  serine/threonine-protein kinase Nek1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC134339, AC159302
      UniProtKB/TrEMBL
      Q69Z74
    7. NM_001414229.1NP_001401158.1  serine/threonine-protein kinase Nek1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC134339, AC159302
      UniProtKB/TrEMBL
      Q69Z74
    8. NM_001414230.1NP_001401159.1  serine/threonine-protein kinase Nek1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC134339, AC159302
    9. NM_175089.4NP_780298.2  serine/threonine-protein kinase Nek1 isoform 3

      See identical proteins and their annotated locations for NP_780298.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded protein (isoform 3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK135564, AY850065, BC070443, CX237035
      Consensus CDS
      CCDS40347.1
      UniProtKB/Swiss-Prot
      P51954
      UniProtKB/TrEMBL
      Q69Z74
      Related
      ENSMUSP00000034065.8, ENSMUST00000034065.14
      Conserved Domains (2) summary
      smart00220
      Location:4258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61446184..61584383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153794.1XP_036009687.1  serine/threonine-protein kinase Nek1 isoform X7

      Conserved Domains (1) summary
      cd08218
      Location:3258
      STKc_Nek1; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1
    2. XM_030243340.2XP_030099200.1  serine/threonine-protein kinase Nek1 isoform X5

      UniProtKB/TrEMBL
      Q69Z74
      Conserved Domains (1) summary
      cl21453
      Location:1179
      PKc_like; Protein Kinases, catalytic domain