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    FAD8 fatty acid desaturase 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830441, updated on 30-Sep-2024

    Summary

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    Official Symbol
    FAD8
    Official Full Name
    fatty acid desaturase 8
    Primary source
    TAIR:AT5G05580
    Locus tag
    AT5G05580
    See related
    Araport:AT5G05580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtFAD8; fatty acid desaturase 8; MOP10.12; MOP10_12; OMEGA-3 FATTY ACID DESATURASE
    Summary
    Encodes a temperature sensitive plastidic fatty acid desaturase.
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    Genomic context

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    See FAD8 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (1664040..1666531)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene sequence-specific DNA binding transcription factor Neighboring gene E3 ubiquitin ligase Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene phosphoribosylanthranilate isomerase 2 Neighboring gene uncharacterized protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 2-Cys peroxiredoxins contribute to thylakoid lipid unsaturation by affecting ω-3 fatty acid desaturase 8. Hernández ML, et al. Plant Physiol, 2024 May 31. PMID 38386701, Free PMC Article
    2. A temperature-sensitive mechanism that regulates post-translational stability of a plastidial omega-3 fatty acid desaturase (FAD8) in Arabidopsis leaf tissues. Matsuda O, et al. J Biol Chem, 2005 Feb 4. PMID 15545277
    3. Cloning of a temperature-regulated gene encoding a chloroplast omega-3 desaturase from Arabidopsis thaliana. Gibson S, et al. Plant Physiol, 1994 Dec. PMID 7846164, Free PMC Article
    4. FAD2 and FAD3 desaturases form heterodimers that facilitate metabolic channeling in vivo. Lou Y, et al. J Biol Chem, 2014 Jun 27. PMID 24811169, Free PMC Article
    5. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. Maeda H, et al. Plant Cell, 2008 Feb. PMID 18314499, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 2-Cys peroxiredoxins contribute to thylakoid lipid unsaturation by affecting omega-3 fatty acid desaturase 8.
      Title: 2-Cys peroxiredoxins contribute to thylakoid lipid unsaturation by affecting ω-3 fatty acid desaturase 8.
    2. the regulation of post-translational stability of FAD8 provides an important regulatory mechanism for modifying its activity in response to temperature
      Title: A temperature-sensitive mechanism that regulates post-translational stability of a plastidial omega-3 fatty acid desaturase (FAD8) in Arabidopsis leaf tissues.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203301.2
    NM_120640.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables omega-3 fatty acid desaturase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to temperature stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    fatty acid desaturase 8
    NP_001190230.1
    • fatty acid desaturase 8 (FAD8); CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3474 (InterPro:IPR021863), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: fatty acid desaturase 7 (TAIR:AT3G11170.1).
    NP_196177.1
    • fatty acid desaturase 8 (FAD8); FUNCTIONS IN: omega-3 fatty acid desaturase activity; INVOLVED IN: response to temperature stimulus, fatty acid biosynthetic process; LOCATED IN: chloroplast, chloroplast envelope; CONTAINS InterPro DOMAIN/s: Protein of unknown function DUF3474 (InterPro:IPR021863), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: fatty acid desaturase 7 (TAIR:AT3G11170.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1664040..1666531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203301.2 → NP_001190230.1  fatty acid desaturase 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UJS8, F4K0R2
      Conserved Domains (3) summary
      cd03507
      Location:105 → 373
      Delta12-FADS-like; The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of ...
      pfam00487
      Location:134 → 379
      FA_desaturase; Fatty acid desaturase
      pfam11960
      Location:2 → 126
      DUF3474; Domain of unknown function (DUF3474)

    2. NM_120640.4 → NP_196177.1  fatty acid desaturase 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48622
      UniProtKB/TrEMBL
      A0A178UJS8, A0A5S9Y1M9, Q8W4M9
      Conserved Domains (1) summary
      PLN02498
      Location:1 → 435
      PLN02498; omega-3 fatty acid desaturase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48622.1

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