Wdr6 WD repeat domain 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wdr6provided by RGD
Official Full Name: WD repeat domain 6provided by RGD
Primary source: RGD:1307649
See related: EnsemblRapid:ENSRNOG00000020185 AllianceGenome:RGD:1307649
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables insulin receptor substrate binding activity. Predicted to be involved in negative regulation of autophagy; negative regulation of cell population proliferation; and wobble position ribose methylation. Predicted to act upstream of with a negative effect on G1 to G0 transition. Part of protein-containing complex. Orthologous to human WDR6 (WD repeat domain 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 182.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118146608..118153024, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109268079..109274504, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117358345..117364761, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI853847 (e-PCR)
- UniSTS:164420

RH137218 (e-PCR)
- UniSTS:219306

BB128974 (e-PCR)
- UniSTS:185807

RH128647 (e-PCR)
- UniSTS:211955

AW530353 (e-PCR)
- UniSTS:261623

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info
enables enzyme regulator activity	ISO Inferred from Sequence Orthology more info
enables enzyme regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor substrate binding	IPI Inferred from Physical Interaction more info	PubMed
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_negative_effect G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in wobble position ribose methylation	IEA Inferred from Electronic Annotation more info
involved_in wobble position ribose methylation	ISO Inferred from Sequence Orthology more info
involved_in wobble position ribose methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of COP9 signalosome	IEA Inferred from Electronic Annotation more info
part_of COP9 signalosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tRNA (34-2'-O)-methyltransferase regulator WDR6

Names: WD repeat domain 6 protein; WD repeat-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006988.2 → NP_001006989.2 tRNA (34-2'-O)-methyltransferase regulator WDR6

See identical proteins and their annotated locations for NP_001006989.2

Status: PROVISIONAL

Source sequence(s)

CH473954

UniProtKB/Swiss-Prot

Q5XFW6

UniProtKB/TrEMBL

A0A8I6AWT4

Related

ENSRNOP00000027411.6, ENSRNOT00000027411.9

Conserved Domains (3) summary

COG2319
Location:84 → 327

WD40; WD40 repeat [General function prediction only]

sd00039
Location:212 → 252

7WD40; WD40 repeat [structural motif]

cl02567
Location:206 → 325

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...