Wdr77 WD repeat domain 77 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr77provided by MGI
Official Full Name: WD repeat domain 77provided by MGI
Primary source: MGI:MGI:1917715
See related: Ensembl:ENSMUSG00000000561 AllianceGenome:MGI:1917715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p44/MEP50; 2610003I18Rik; 2610312E17Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Part of Cul4B-RING E3 ubiquitin ligase complex. Is expressed in genitourinary system. Orthologous to human WDR77 (WD repeat domain 77). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 34.7), liver adult (RPKM 22.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.2; 3 46.46 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (105866814..105877076)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (105959498..105969760)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
Title: WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response.
MEP50 associated with the purinergic receptor P2X5 and is involved in osteoclast maturation.
Title: Methylosome protein 50 associates with the purinergic receptor P2X5 and is involved in osteoclast maturation.
Wdr77 ablation inhibited E2F3 activation and enhanced TGFbeta signaling, leading to attenuated cellular proliferation induced by loss of Pten.
Title: The essential role of WD repeat domain 77 in prostate tumor initiation induced by Pten loss.
WDR77 expression is associated with E2F1, E2F3, GATA2 and GATA6 occupancy on the WDR77 gene, whereas, in contrast, E2F6, GATA1 and GATA3 occupancy is associated with the loss of WDR77 expression during erythroid maturation and lung development
Title: E2F and GATA switches turn off WD repeat domain 77 expression in differentiating cells.
These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function.
Title: cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.
p44/wdr77 controls cellular proliferation during lung development, and this growth process is reactivated during lung tumorigenesis
Title: The p44/wdr77-dependent cellular proliferation process during lung development is reactivated in lung cancer.
Silencing p21(Cip1) or NF-kappaB p65 expression with short hairpin RNA (shRNA) abolished astrocyte activation and rescued the astrocyte growth inhibition induced by deletion of the p44/WDR77 gene.
Title: Loss of the androgen receptor cofactor p44/WDR77 induces astrogliosis.
These results provide a basis for understanding subcellular transport of p44/WDR77 during prostate development and tumorigenesis.
Title: Nuclear transport signals control cellular localization and function of androgen receptor cofactor p44/WDR77.
The AR cofactor p44/WDR77 plays important roles in prostate growth and differentiation by modulating AR-target gene expression.
Title: Altered differentiation and proliferation of prostate epithelium in mice lacking the androgen receptor cofactor p44/WDR77.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte axis specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of mRNA splicing, via spliceosome	NAS Non-traceable Author Statement more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal snRNP assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4B-RING E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of methylosome	IBA Inferred from Biological aspect of Ancestor more info
part_of methylosome	ISO Inferred from Sequence Orthology more info
part_of methylosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: methylosome protein WDR77

Names: MEP-50; WD repeat-containing protein 77; methylosome protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027432.3 → NP_081708.1 methylosome protein WDR77

See identical proteins and their annotated locations for NP_081708.1

Status: PROVISIONAL

Source sequence(s)

AK050391

Consensus CDS

CCDS17715.1

UniProtKB/Swiss-Prot

Q3TFJ1, Q8BSH8, Q99J09, Q9CZY5

Related

ENSMUSP00000010278.6, ENSMUST00000010278.12

Conserved Domains (3) summary

COG2319
Location:98 → 322

WD40; WD40 repeat [General function prediction only]

sd00039
Location:83 → 120

7WD40; WD40 repeat [structural motif]

cl02567
Location:80 → 319

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...