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    Iqcg IQ motif containing G [ Mus musculus (house mouse) ]

    Gene ID: 69707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqcgprovided by MGI
    Official Full Name
    IQ motif containing Gprovided by MGI
    Primary source
    MGI:MGI:1916957
    See related
    Ensembl:ENSMUSG00000035578 AllianceGenome:MGI:1916957
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    repro1; esgd12d; G1-374-12; stubby12d; 2400003L07Rik
    Summary
    Enables calmodulin binding activity. Involved in sperm axoneme assembly. Located in cytoplasm; manchette; and sperm flagellum. Is active in cytosol. Is expressed in brain; lung epithelium; and nose. Orthologous to human IQCG (IQ motif containing G). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.8), testis adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Iqcg in Genome Data Viewer
    Location:
    16 B3; 16 23.55 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32834640..32876617, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33014270..33057145, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4167 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene predicted gene 6611 Neighboring gene nuclear encoded rRNA 5S 33 Neighboring gene STARR-seq mESC enhancer starr_40679 Neighboring gene STARR-positive B cell enhancer ABC_E8628 Neighboring gene STARR-positive B cell enhancer ABC_E2460 Neighboring gene ribosomal protein L35A Neighboring gene leishmanolysin-like (metallopeptidase M8 family) Neighboring gene microRNA 1947

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Iqcg is essential for sperm flagellum formation in mice. Li RK, et al. PLoS One, 2014. PMID 24849454, Free PMC Article
    2. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. Harris TP, et al. G3 (Bethesda), 2014 Feb 19. PMID 24362311, Free PMC Article
    3. Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. Ward JO, et al. Biol Reprod, 2003 Nov. PMID 12855593
    4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iqcg is specifically required for spermiogenesis in mammals
      Title: Iqcg is essential for sperm flagellum formation in mice.
    2. Loss of Iqcg disrupts spermiogenesis such that tail formation either occurs incompletely or breaks apart from the sperm heads.
      Title: IQ motif-containing G (Iqcg) is required for mouse spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in manchette IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dynein regulatory complex protein 9
    Names
    IQ domain-containing protein G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178378.3 → NP_848465.1  dynein regulatory complex protein 9

      Status: VALIDATED

      Source sequence(s)
      AC126023, BC049990, BY120455
      Consensus CDS
      CCDS37316.1
      UniProtKB/Swiss-Prot
      Q80W32
      Related
      ENSMUSP00000110752.2, ENSMUST00000115100.9
      Conserved Domains (1) summary
      pfam04111
      Location:202 → 343
      APG6; Autophagy protein Apg6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32834640..32876617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522519.5 → XP_006522582.1  dynein regulatory complex protein 9 isoform X2

      Conserved Domains (1) summary
      pfam04111
      Location:139 → 280
      APG6; Autophagy protein Apg6

    2. XM_011246004.4 → XP_011244306.1  dynein regulatory complex protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q80W32
      Conserved Domains (1) summary
      pfam04111
      Location:202 → 343
      APG6; Autophagy protein Apg6

    3. XM_006522520.5 → XP_006522583.1  dynein regulatory complex protein 9 isoform X3

      Conserved Domains (1) summary
      pfam04111
      Location:69 → 210
      APG6; Autophagy protein Apg6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80W32.1 GenPept UniProtKB/Swiss-Prot:Q80W32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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