Tmem41b transmembrane protein 41B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmem41bprovided by MGI
Official Full Name: transmembrane protein 41Bprovided by MGI
Primary source: MGI:MGI:1289225
See related: Ensembl:ENSMUSG00000047554 AllianceGenome:MGI:1289225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D7Ertd70e; D7Ertd743e; 1500015G02Rik; 1500031M19Rik
Summary: Predicted to enable phospholipid scramblase activity. Predicted to be involved in autophagosome assembly; intracellular lipid transport; and modulation by host of viral RNA genome replication. Located in mitochondria-associated endoplasmic reticulum membrane contact site. Is expressed in embryo. Orthologous to human TMEM41B (transmembrane protein 41B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 10.3), cerebellum adult (RPKM 8.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 57.69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (109570422..109586011, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (109971215..109986804, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stasimon/Tmem41b is required for cell proliferation and adult mouse survival.
Title: Stasimon/Tmem41b is required for cell proliferation and adult mouse survival.
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Title: TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication.
Title: Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replication.
Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Title: Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy.
Stasimon is an essential gene for mouse embryonic development.
Title: Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.
Defective U12 splicing and reduced mRNA levels of Stasimon (NP_705745) was observed in the motor circuit neurons of mice with spinal muscular atrophy.
Title: An SMN-dependent U12 splicing event essential for motor circuit function.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Ertd743e (e-PCR), detects polymorphism
- UniSTS:167542

RH126243 (e-PCR)
- UniSTS:162951

AU018901 (e-PCR)
- UniSTS:159910

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipid scramblase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular lipid transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular lipid transport	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral RNA genome replication	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral RNA genome replication	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondria-associated endoplasmic reticulum membrane contact site	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondria-associated endoplasmic reticulum membrane contact site	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 41B

Names: Stasimon; protein stasimon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.