U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Csn1s2a casein alpha s2-like A [ Mus musculus (house mouse) ]

    Gene ID: 12993, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Csn1s2aprovided by MGI
    Official Full Name
    casein alpha s2-like Aprovided by MGI
    Primary source
    MGI:MGI:88542
    See related
    Ensembl:ENSMUSG00000061937 AllianceGenome:MGI:88542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csng; PP22
    Summary
    Predicted to enable protein homodimerization activity and zymogen binding activity. Located in extracellular region. Is expressed in jaw bone; nervous system; sensory organ; and thoracic segment skeleton. Orthologous to human CSN1S2AP (casein alpha s2 like A, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Csn1s2a in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87922309..87936657)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87774450..87788798)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25066 Neighboring gene STARR-seq mESC enhancer starr_13563 Neighboring gene predicted gene, 24314 Neighboring gene casein alpha s2-like B Neighboring gene STARR-seq mESC enhancer starr_13564 Neighboring gene proline rich 27

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mouse gamma-casein cDNA: PCR cloning and sequence analysis. Sasaki T, et al. Zoolog Sci, 1993 Feb. PMID 7763793
    2. Structure and regulation of the murine gamma-casein gene. Kolb AF. Biochim Biophys Acta, 2002 Dec 12. PMID 12427545
    3. Prolactin-dependent growth and gamma-casein gene expression in Ba/F3 cells transfected with a long form of mouse mammary prolactin receptor. Sasaki M, et al. Endocr J, 1996 Feb. PMID 8732451
    4. Localization of the casein gene family to a single mouse chromosome. Gupta P, et al. J Cell Biol, 1982 Apr. PMID 6896059, Free PMC Article
    5. Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. Hennighausen LG, et al. Eur J Biochem, 1982 Jun 15. PMID 6896688

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zymogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alpha-S2-casein-like A
    Names
    gamma casein
    milk protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304765.1 → NP_001291694.1  alpha-S2-casein-like A isoform 2 precursor

      See identical proteins and their annotated locations for NP_001291694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC074046, AK164738, BB661763
      Consensus CDS
      CCDS80318.1
      UniProtKB/TrEMBL
      Q3TP41
      Related
      ENSMUSP00000143715.2, ENSMUST00000196749.5

    2. NM_001304767.1 → NP_001291696.1  alpha-S2-casein-like A isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC074046, AK142688, BB661763
      Consensus CDS
      CCDS84901.1
      UniProtKB/TrEMBL
      A0A0G2JET6
      Related
      ENSMUSP00000142901.2, ENSMUST00000200322.5

    3. NM_001304768.1 → NP_001291697.1  alpha-S2-casein-like A isoform 5 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 5), compared to isoform 1.
      Source sequence(s)
      AC074046, AK142688, BB661763
      Consensus CDS
      CCDS84900.1
      UniProtKB/TrEMBL
      A0A0G2JGC6
      Related
      ENSMUSP00000143515.2, ENSMUST00000196585.2

    4. NM_001304769.1 → NP_001291698.1  alpha-S2-casein-like A isoform 4 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC074046, AK142688, BB661763
      UniProtKB/TrEMBL
      Q547D1

    5. NM_007785.2 → NP_031811.1  alpha-S2-casein-like A isoform 1 precursor

      See identical proteins and their annotated locations for NP_031811.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC074046, AK142688, BB661763
      Consensus CDS
      CCDS39132.1
      UniProtKB/Swiss-Prot
      Q02862
      UniProtKB/TrEMBL
      Q547D1
      Related
      ENSMUSP00000075716.4, ENSMUST00000076379.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      87922309..87936657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02862.1 GenPept UniProtKB/Swiss-Prot:Q02862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools