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    Myoz3 myozenin 3 [ Mus musculus (house mouse) ]

    Gene ID: 170947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myoz3provided by MGI
    Official Full Name
    myozenin 3provided by MGI
    Primary source
    MGI:MGI:2179296
    See related
    Ensembl:ENSMUSG00000049173 AllianceGenome:MGI:2179296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fatz-3; 4833419K08Rik
    Summary
    Predicted to enable FATZ binding activity; actin binding activity; and telethonin binding activity. Located in Z disc. Is expressed in heart; skeletal muscle; and stomach. Orthologous to human MYOZ3 (myozenin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 4.7), lung adult (RPKM 0.8) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Myoz3 in Genome Data Viewer
    Location:
    18 D3; 18 34.36 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (60706789..60724931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60573717..60591716, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene dynactin 4 Neighboring gene STARR-positive B cell enhancer ABC_E9978 Neighboring gene predicted gene, 52358 Neighboring gene RNA binding motif protein 22 Neighboring gene synaptopodin Neighboring gene STARR-seq mESC enhancer starr_44719 Neighboring gene RIKEN cDNA G630071F17 gene Neighboring gene VISTA enhancer mm1623

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A class III PDZ binding motif in the myotilin and FATZ families binds enigma family proteins: a common link for Z-disc myopathies. von Nandelstadh P, et al. Mol Cell Biol, 2009 Feb. PMID 19047374, Free PMC Article
    2. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. Frey N, et al. J Biol Chem, 2002 Apr 19. PMID 11842093
    3. Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Liu TY, et al. Open Biol, 2017 Jan. PMID 28077597, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
      Title: Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123456, MGC123457

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FATZ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telethonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myozenin-3
    Names
    FATZ-related protein 3
    calsarcin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133363.4 → NP_579941.2  myozenin-3

      Status: VALIDATED

      Source sequence(s)
      AC149216
      Consensus CDS
      CCDS29273.1
      UniProtKB/Swiss-Prot
      Q8R4E4
      UniProtKB/TrEMBL
      E9QJU4
      Related
      ENSMUSP00000063108.8, ENSMUST00000056533.9
      Conserved Domains (1) summary
      pfam05556
      Location:1 → 245
      Calsarcin; Calcineurin-binding protein (Calsarcin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      60706789..60724931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4E4.1 GenPept UniProtKB/Swiss-Prot:Q8R4E4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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