Saa3 serum amyloid A 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Saa3provided by MGI
Official Full Name: serum amyloid A 3provided by MGI
Primary source: MGI:MGI:98223
See related: Ensembl:ENSMUSG00000040026 AllianceGenome:MGI:98223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: l7R3; Saa-3
Summary: Enables Toll-like receptor 4 binding activity and chemoattractant activity. Involved in response to stilbenoid. Acts upstream of or within several processes, including I-kappaB phosphorylation; cell chemotaxis; and cellular response to interleukin-1. Located in extracellular space. Is expressed in several structures, including cerebellum; ileum; liver; reproductive system; and thymus. Orthologous to human SAA3P (serum amyloid A3, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E18 (RPKM 11.8), genital fat pad adult (RPKM 2.2) and 8 other tissues See more
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Genomic context

Location:: 7 B3; 7 30.51 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (46361422..46365100, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (46711998..46719615, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism of Cholesterol.
Title: Osteocytes/Osteoblasts Produce SAA3 to Regulate Hepatic Metabolism of Cholesterol.
Serum amyloid A3 deficiency impairs in vitro and in vivo adipocyte differentiation.
Title: Serum amyloid A3 deficiency impairs in vitro and in vivo adipocyte differentiation.
Mycobacterium tuberculosis stimulates IL-1beta production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3.
Title: Mycobacterium tuberculosis stimulates IL-1β production by macrophages in an ESAT-6 dependent manner with the involvement of serum amyloid A3.
In vitro and ex vivo expression of serum amyloid A3 in mouse lung epithelia.
Title: In vitro and ex vivo expression of serum amyloid A3 in mouse lung epithelia.
Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.
Title: Sexually Dimorphic Relationships Among Saa3 (Serum Amyloid A3), Inflammation, and Cholesterol Metabolism Modulate Atherosclerosis in Mice.
The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
Title: The serum amyloid A3 promoter-driven luciferase reporter mice is a valuable tool to image early renal fibrosis development and shows the therapeutic effect of glucosyl-hesperidin treatment.
Potential of Mesenchymal stem cells-exosomes overexpressing miR-30b-3p in preventing acute lung injury. These exosomes protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3.
Title: Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3.
These findings demonstrate that SAA3 not only serves as a biomarker for infection and inflammation, but also plays a protective role against P. aeruginosa infection-induced lung injury.
Title: Serum amyloid A3 confers protection against acute lung injury in Pseudomonas aeruginosa-infected mice.
Up-regulation of serum amyloid A3 mRNA expression after stimulation with lipopolysaccharide and lipoteichoic acid in mouse lung cells.
Title: Up-regulation of serum amyloid A3 mRNA expression after stimulation with lipopolysaccharide and lipoteichoic acid in mouse lung cells.
Findings indicate that endogenous SAA3 regulates lung development and homeostasis, and is required for protection against H1N1 influenza infection.
Title: Serum Amyloid A3 is required for normal lung development and survival following influenza infection.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (5) 1 citation
Targeted (2)

General gene information

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Markers

RH137346 (e-PCR)
- UniSTS:219434

Saa3 (e-PCR), detects polymorphism
- UniSTS:525447

AV098916 (e-PCR)
- UniSTS:165526

PMC153489P2 (e-PCR)
- UniSTS:271255

NoName (e-PCR)
- UniSTS:235671

X03505 (e-PCR)
- UniSTS:159645

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Toll-like receptor 4 binding	IPI Inferred from Physical Interaction more info	PubMed
enables chemoattractant activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to interleukin-1	IDA Inferred from Direct Assay more info	PubMed
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serum amyloid A-3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.