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    Smr2 submaxillary gland androgen regulated protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 20600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smr2provided by MGI
    Official Full Name
    submaxillary gland androgen regulated protein 2provided by MGI
    Primary source
    MGI:MGI:102762
    See related
    Ensembl:ENSMUSG00000029281 AllianceGenome:MGI:102762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSG2; Vcs2
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in regulation of sensory perception of pain. Predicted to be located in extracellular region. Orthologous to human SMR3B (submaxillary gland androgen regulated protein 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Smr2 in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88234415..88256912)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88086556..88109053)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene submaxillary gland androgen regulated protein 3A Neighboring gene heat shock protein 5 pseudogene Neighboring gene predicted gene 42622 Neighboring gene heat shock protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mouse Vcs2 gene is a composite structure which evolved by gene fusion and encodes five distinct salivary mRNA species. Señorale-Pose M, et al. Gene, 1997 Nov 12. PMID 9409774
    2. Three novel SMR1-related cDNAs characterized in the submaxillary gland of mice show extensive evolutionary divergence in the protein coding region. Tronik-Le Roux D, et al. Gene, 1994 May 16. PMID 8194749
    3. Opiorphin is a master regulator of the hypoxic response in corporal smooth muscle cells. Fu S, et al. FASEB J, 2014 Aug. PMID 24803544, Free PMC Article
    4. Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Erdreich-Epstein A, et al. Genes Chromosomes Cancer, 2006 Feb. PMID 16252261
    5. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Qi L, et al. Cell, 2024 Mar 14. PMID 38442711,

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130573

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of sensory perception of pain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    submaxillary gland androgen regulated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252679.1 → NP_001239608.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains two alternate internal exons and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154123, AC163331
      Consensus CDS
      CCDS80321.1
      UniProtKB/Swiss-Prot
      O35979, Q2NKH7
      Related
      ENSMUSP00000143443.2, ENSMUST00000196070.2
      Conserved Domains (1) summary
      pfam15621
      Location:1 → 111
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    2. NM_001252680.1 → NP_001239609.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154123, AC163331
      Consensus CDS
      CCDS80321.1
      UniProtKB/Swiss-Prot
      O35979, Q2NKH7
      Conserved Domains (1) summary
      pfam15621
      Location:1 → 111
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    3. NM_001252681.1 → NP_001239610.1  submaxillary gland androgen regulated protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001239610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, contains an alternate internal exon and initiates translation at an alternate start codon, compared to variant 1. Variants 2, 3 and 4 encode the same isoform (2) which has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154123, AC163331
      Consensus CDS
      CCDS80321.1
      UniProtKB/Swiss-Prot
      O35979, Q2NKH7
      Related
      ENSMUSP00000142688.2, ENSMUST00000196477.5
      Conserved Domains (1) summary
      pfam15621
      Location:1 → 111
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    4. NM_021289.2 → NP_067264.2  submaxillary gland androgen regulated protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_067264.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC154123, AC163331
      Consensus CDS
      CCDS39137.1
      UniProtKB/Swiss-Prot
      O35985
      Related
      ENSMUSP00000084271.4, ENSMUST00000087043.8
      Conserved Domains (1) summary
      pfam15621
      Location:1 → 111
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      88234415..88256912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254268.1 → XP_030110128.1  submaxillary gland androgen regulated protein 2 isoform X1

      UniProtKB/Swiss-Prot
      O09133
      Related
      ENSMUSP00000142444.2, ENSMUST00000199635.5
      Conserved Domains (1) summary
      pfam15621
      Location:1 → 116
      PROL5-SMR; Proline-rich submaxillary gland androgen-regulated family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09133.1 GenPept UniProtKB/Swiss-Prot:O09133
    O35961.1 GenPept UniProtKB/Swiss-Prot:O35961
    O35979.1 GenPept UniProtKB/Swiss-Prot:O35979
    O35982.1 GenPept UniProtKB/Swiss-Prot:O35982
    O35985.1 GenPept UniProtKB/Swiss-Prot:O35985

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