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    Ltn1 listerin E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 78913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ltn1provided by MGI
    Official Full Name
    listerin E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1926163
    See related
    Ensembl:ENSMUSG00000052299 AllianceGenome:MGI:1926163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf160; Zfp294; Listerin; 4930528H02Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein autoubiquitination. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including genitourinary system; gut; nervous system; sensory organ; and thymus. Orthologous to human LTN1 (listerin E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.3), CNS E18 (RPKM 6.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ltn1 in Genome Data Viewer
    Location:
    16 C3.3; 16 49.52 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87173539..87229504, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87376651..87432619, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41484 Neighboring gene STARR-seq mESC enhancer starr_41395 Neighboring gene STARR-positive B cell enhancer ABC_E4185 Neighboring gene N-6 adenine-specific DNA methyltransferase 1 (putative) Neighboring gene STARR-positive B cell enhancer ABC_E1186 Neighboring gene predicted gene, 25896 Neighboring gene STARR-positive B cell enhancer ABC_E11624 Neighboring gene RWD domain containing 2B Neighboring gene STARR-positive B cell enhancer ABC_E10922 Neighboring gene ubiquitin specific peptidase 16 Neighboring gene chaperonin containing TCP1 subunit 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response. Qin F, et al. Proc Natl Acad Sci U S A, 2023 Dec 26. PMID 38109536, Free PMC Article
    2. LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway. Qin F, et al. Autophagy, 2024 Jun. PMID 38060409, Free PMC Article
    3. Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3. Endo R, et al. Proc Natl Acad Sci U S A, 2023 Mar 21. PMID 36917672, Free PMC Article
    4. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Chu J, et al. Proc Natl Acad Sci U S A, 2009 Feb 17. PMID 19196968, Free PMC Article
    5. Novel pancreas organogenesis markers refine the pancreatic differentiation roadmap of embryonic stem cells. De Angelis MT, et al. Stem Cell Rev Rep, 2014 Apr. PMID 24390927

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.
      Title: LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.
    2. Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response.
      Title: Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response.
    3. LISTERIN is an E3 ubiquitin ligase involved in neurodegeneration.
      Title: A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0714

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribosomal large subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RQC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase listerin
    Names
    RING-type E3 ubiquitin transferase listerin
    ring finger protein 160
    zfp-294
    zinc finger protein 294
    NP_001074537.1
    NP_001402964.1
    XP_036016076.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081068.2 → NP_001074537.1  E3 ubiquitin-protein ligase listerin isoform 1

      See identical proteins and their annotated locations for NP_001074537.1

      Status: VALIDATED

      Source sequence(s)
      AC140319
      Consensus CDS
      CCDS37382.1
      UniProtKB/Swiss-Prot
      E9QN94, Q6A009, Q6PIW6, Q8BZ44
      Related
      ENSMUSP00000038775.8, ENSMUST00000039449.9
      Conserved Domains (1) summary
      pfam13639
      Location:1714 → 1763
      zf-RING_2; Ring finger domain

    2. NM_001416035.1 → NP_001402964.1  E3 ubiquitin-protein ligase listerin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140319

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      87173539..87229504 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160183.1 → XP_036016076.1  E3 ubiquitin-protein ligase listerin isoform X1

      Conserved Domains (1) summary
      COG5219
      Location:640 → 928
      COG5219; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

    RNA

    1. XR_384950.5 RNA Sequence

    2. XR_384951.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A009.3 GenPept UniProtKB/Swiss-Prot:Q6A009

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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