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    QCR9 ubiquinol--cytochrome-c reductase subunit 9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    QCR9
    Official Full Name
    ubiquinol--cytochrome-c reductase subunit 9
    Primary source
    SGD:S000003415
    Locus tag
    YGR183C
    See related
    AllianceGenome:SGD:S000003415; FungiDB:YGR183C; VEuPathDB:YGR183C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    UCR9
    Summary
    Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Part of respiratory chain complex III. Orthologous to human UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See QCR9 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    2
    Sequence:
    Chromosome: VII; NC_001139.9 (859063..859476, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Leu Neighboring gene protein translocase subunit TIM13 Neighboring gene E3 ubiquitin-protein ligase UBR1 Neighboring gene tyrosine--tRNA ligase TYS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deletion of subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex specifically impairs electron transfer at the ubiquinol oxidase site (center P) in the bc1 complex. Graham LA, et al. FEBS Lett, 1992 Nov 30. PMID 1332881
    2. Isolation and characterization of QCR9, a nuclear gene encoding the 7.3-kDa subunit 9 of the Saccharomyces cerevisiae ubiquinol-cytochrome c oxidoreductase complex. An intron-containing gene with a conserved sequence occurring in the intron of COX4. Phillips JD, et al. J Biol Chem, 1990 Dec 5. PMID 2174427
    3. Subunit 9 of the Saccharomyces cerevisiae cytochrome bc1 complex is required for insertion of EPR-detectable iron-sulfur cluster into the Rieske iron-sulfur protein. Phillips JD, et al. J Biol Chem, 1993 Jun 5. PMID 8389362
    4. A pathogenic cytochrome b mutation reveals new interactions between subunits of the mitochondrial bc1 complex. Saint-Georges Y, et al. J Biol Chem, 2002 Dec 20. PMID 12384503
    5. Enhanced hexose fermentation by Saccharomyces cerevisiae through integration of stoichiometric modeling and genetic screening. Quarterman J, et al. J Biotechnol, 2015 Jan 20. PMID 25435378

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquinol-cytochrome-c reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase subunit 9
    NP_011699.1
    • Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      859063..859476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181312.1 → NP_011699.1  TPA: ubiquinol--cytochrome-c reductase subunit 9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011699.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUW6, P22289
      UniProtKB/TrEMBL
      A6ZUJ4, C8Z977, G2WER2
      Conserved Domains (1) summary
      pfam05365
      Location:4 → 56
      UCR_UQCRX_QCR9; Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22289.2

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