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    HXT4 hexose transporter HXT4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT4
    Official Full Name
    hexose transporter HXT4
    Primary source
    SGD:S000001134
    Locus tag
    YHR092C
    See related
    AllianceGenome:SGD:S000001134; FungiDB:YHR092C; VEuPathDB:YHR092C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LGT1; RAG1
    Summary
    Enables D-glucose transmembrane transporter activity and pentose transmembrane transporter activity. Predicted to be involved in carbohydrate transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (287081..288811, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase YNG2 Neighboring gene arginine--tRNA ligase MSR1 Neighboring gene Aht1p Neighboring gene hexose transporter HXT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of glucose on xylose utilization in Saccharomyces cerevisiae harboring the xylose reductase gene. Han JH, et al. Arch Microbiol, 2011 May. PMID 21279628
    2. Glucose sensing and signalling properties in Saccharomyces cerevisiae require the presence of at least two members of the glucose transporter family. Walsh MC, et al. J Bacteriol, 1996 May. PMID 8626327, Free PMC Article
    3. Characterization of the xylose-transporting properties of yeast hexose transporters and their influence on xylose utilization. Hamacher T, et al. Microbiology (Reading), 2002 Sep. PMID 12213924
    4. Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast. Sedlak M, et al. Yeast, 2004 Jun. PMID 15197732
    5. Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae. Ozcan S, et al. J Bacteriol, 1993 Sep. PMID 8366037, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
      Title: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables pentose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT4
    NP_011960.2
    • High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      287081..288811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179222.2 → NP_011960.2  TPA: hexose transporter HXT4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011960.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZT02, D3DL44, P32467
      UniProtKB/TrEMBL
      G2WFG7
      Conserved Domains (1) summary
      pfam00083
      Location:74 → 534
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32467.1

    Gene LinkOut

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