Btg3 BTG anti-proliferation factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Btg3provided by RGD
Official Full Name: BTG anti-proliferation factor 3provided by RGD
Primary source: RGD:2226
See related: EnsemblRapid:ENSRNOG00000001555 AllianceGenome:RGD:2226
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in response to oxidative stress. Predicted to be active in cytoplasm and nucleus. Orthologous to human BTG3 (BTG anti-proliferation factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 169.4), Testes (RPKM 153.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (30517068..30532981, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (17030156..17046069, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (16873642..16889100, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BTG3, a novel, direct target of miR-142-5p, negatively regulates VSMC proliferation
Title: B cell translocation gene, a direct target of miR-142-5p, inhibits vascular smooth muscle cell proliferation by down-regulating cell cycle progression.
Fndings suggest that the induction of the Btg3 may be important for theca and granulosa cell differentiation into luteal cells by arresting cell cycle progression.
Title: The B cell translocation gene (BTG) family in the rat ovary: hormonal induction, regulation, and impact on cell cycle kinetics.
by controlling the basal threshold of Src activity, constitutes an important negative regulatory mechanism for Src-mediated signalling.
Title: APRO4 negatively regulates Src tyrosine kinase activity in PC12 cells.

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General gene information

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Markers

Btg3 (e-PCR), detects polymorphism
- UniSTS:259587

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of cell population proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein BTG3

Names: B-cell translocation gene 3; BTG family, member 3; rBTG3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019290.2 → NP_062163.2 protein BTG3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/Swiss-Prot

O88677

UniProtKB/TrEMBL

A0JPM2, A6JL38, F7FB02

Related

ENSRNOP00000002121.2, ENSRNOT00000002121.5

Conserved Domains (1) summary

smart00099
Location:1 → 108

btg1; tob/btg1 family