Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Atp2a1provided by RGD
Official Full Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1provided by RGD
Primary source: RGD:621293
See related: EnsemblRapid:ENSRNOG00000047124 AllianceGenome:RGD:621293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Serca1
Summary: Enables several functions, including ATP binding activity; P-type calcium transporter activity; and calcium-dependent ATPase activity. Involved in calcium ion transmembrane transport; response to peptide hormone; and sarcoplasmic reticulum calcium ion transport. Acts upstream of or within calcium ion transport. Located in sarcoplasmic reticulum. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brody myopathy. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 42628.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190457198..190475410, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181026606..181044859, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197855912..197875038, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In acute stages of sepsis, the improvement of SERCA function could reduce the disequilibrium of calcium homeostasis to improve the critical illness myopathy and respiratory failure.
Title: SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis.
This study demonstrated that Slowed relaxation of the diaphragm in septic rats was associated with reduced expression of SERCA1.
Title: Slowed relaxation of diaphragm in septic rats is associated with reduced expression of sarco-endoplasmic reticulum CA(2+) -ATPase genes SERCA1 and SERCA2.
SERCA has a role in sarcoplasmic reticulum calcium content and calcium wave propagation in rat ventricular myocytes
Title: Role of SERCA and the sarcoplasmic reticulum calcium content on calcium waves propagation in rat ventricular myocytes.
these results suggest that sAnk1 interacts with SERCA1 through its TM and cytoplasmic domains to regulate SERCA1 activity and modulate sequestration of Ca(2+) in the sarcoplasmic reticulum lumen.
Title: Identification of Small Ankyrin 1 as a Novel Sarco(endo)plasmic Reticulum Ca2+-ATPase 1 (SERCA1) Regulatory Protein in Skeletal Muscle.
Thus the human SERCA1b has a different expression pattern from that of rodents and it is associated with DM2.
Title: The neonatal sarcoplasmic reticulum Ca2+-ATPase gives a clue to development and pathology in human muscles.
Compared with spinal isolation, spasticity promoted parvalbumin recovery (ninefold increase) and a SERCA2-to-SERCA1 transformation (84% increase in the ratio of SERCA1 to SERCA2) in tail muscle.
Title: Tail muscle parvalbumin content is decreased in chronic sacral spinal cord injured rats with spasticity.
changes between enzyme activity and fluorescence isothiocyanate binding suggest that, at least during recovery after exercise, changes in SERCA activity may not correlate with structural alterations to the adenine nucleotide binding site within the enzyme
Title: No relationship between enzyme activity and structure of nucleotide binding site in sarcoplasmic reticulum Ca(2+)-ATPase from short-term stimulated rat muscle.
SERCA1 levels were not different on immunoblots of the soleus of streptozocin-treated and control rats.
Title: The slow sarco/endoplasmic reticulum Ca2+ -ATPase declines independently of slow myosin in soleus muscle of diabetic rats.
Concluded that increased SERCA activity in adjuvant arthritis was due to increased levels of SERCA protein and structural changes to the protein, probably induced by direct and specific oxidation involving reactive nitrogen species.
Title: Modulation of SERCA in the chronic phase of adjuvant arthritis as a possible adaptation mechanism of redox imbalance.
These results suggest that impairment of the SERCA function may be an early event in excitotoxicity.
Title: Quinolinate-induced rat striatal excitotoxicity impairs endoplasmic reticulum Ca2+-ATPase function.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI462746 (e-PCR)
- UniSTS:164365

RH131787 (e-PCR)
- UniSTS:215070

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables P-type calcium transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide-sugar transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IEA Inferred from Electronic Annotation more info
involved_in apoptotic mitochondrial changes	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import into sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate derivative transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in maintenance of mitochondrion location	IEA Inferred from Electronic Annotation more info
involved_in maintenance of mitochondrion location	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of striated muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleobase-containing compound transport	IEA Inferred from Electronic Annotation more info
involved_in organophosphate ester transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion import into sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle cell contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endoplasmic reticulum calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endoplasmic reticulum calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fast-twitch skeletal muscle fiber contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fast-twitch skeletal muscle fiber contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fast-twitch skeletal muscle fiber contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitochondrial calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of striated muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of striated muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in relaxation of skeletal muscle	IEA Inferred from Electronic Annotation more info
involved_in relaxation of skeletal muscle	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcoplasmic reticulum calcium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in H zone	ISO Inferred from Sequence Orthology more info
located_in H zone	ISS Inferred from Sequence or Structural Similarity more info
located_in I band	ISO Inferred from Sequence Orthology more info
located_in I band	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sarcoplasmic/endoplasmic reticulum calcium ATPase 1

Names: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarco/endoplasmic reticulum calcium ATPase 1; sarco/endoplasmic reticulum calcium ATPase 1a; sarco/endoplasmic reticulum calcium ATPase 1b

NP_478120.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_058213.2 → NP_478120.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 1

See identical proteins and their annotated locations for NP_478120.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q64578

UniProtKB/TrEMBL

A6I958, B4F7E5

Related

ENSRNOP00000091865.1, ENSRNOT00000106738.2

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:93 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:4 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:611 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 528

Cation_ATPase; Cation transport ATPase (P-type)